Jacqueline M Matthews
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Explore the profile of Jacqueline M Matthews including associated specialties, affiliations and a list of published articles.
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90
Citations
2133
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Recent Articles
1.
Low J, Patel K, Jones N, Solomon P, Norman A, Maxwell J, et al.
J Biol Chem
. 2023 Nov;
299(12):105482.
PMID: 37992806
Bromodomains (BDs) regulate gene expression by recognizing protein motifs containing acetyllysine. Although originally characterized as histone-binding proteins, it has since become clear that these domains interact with other acetylated proteins,...
2.
El-Kamand S, Adams M, Matthews J, Du Plessis M, Crossett B, Connolly A, et al.
Protein Sci
. 2023 Sep;
32(10):e4782.
PMID: 37705456
The repair of double-strand DNA breaks (DSBs) by homologous recombination is crucial in the maintenance of genome integrity. While the key role of the Mre11-Rad50-Nbs1 (MRN) complex in repair is...
3.
Desmarini D, Truong D, Wilkinson-White L, Desphande C, Torrado M, Mackay J, et al.
Biomolecules
. 2022 Oct;
12(10).
PMID: 36291735
New antifungals with unique modes of action are urgently needed to treat the increasing global burden of invasive fungal infections. The fungal inositol polyphosphate kinase (IPK) pathway, comprised of IPKs...
4.
Langley D, Schofield P, Nevoltris D, Jackson J, Jackson K, Peters T, et al.
Proc Natl Acad Sci U S A
. 2022 Jul;
119(28):e2123212119.
PMID: 35867757
Humans lack the capacity to produce the Galα1-3Galβ1-4GlcNAc (α-gal) glycan, and produce anti-α-gal antibodies upon exposure to the carbohydrate on a diverse set of immunogens, including commensal gut bacteria, malaria...
5.
Walport L, Low J, Matthews J, Mackay J
Chem Soc Rev
. 2021 Sep;
50(22):12292-12307.
PMID: 34581717
Protein interactions underlie most molecular events in biology. Many methods have been developed to identify protein partners, to measure the affinity with which these biomolecules interact and to characterise the...
6.
Smith N, Wilkinson-White L, Kwan A, Trewhella J, Matthews J
J Struct Biol X
. 2021 Jan;
5:100043.
PMID: 33458649
The roles of ISL1 and LHX3 in the development of spinal motor neurons have been well established. Whereas LHX3 triggers differentiation into interneurons, the additional expression of ISL1 in developing...
7.
Smith N, Kuravsky M, Shammas S, Matthews J
Curr Opin Struct Biol
. 2020 Nov;
66:156-162.
PMID: 33248428
Transcription factors are among the classes of proteins with the highest levels of disorder. Investigation of these regulatory proteins is uncovering not just the mechanisms that underlie gene regulation, but...
8.
Patel K, Walport L, Walshe J, Solomon P, Low J, Tran D, et al.
Proc Natl Acad Sci U S A
. 2020 Oct;
117(43):26728-26738.
PMID: 33046654
Cyclic peptide library screening technologies show immense promise for identifying drug leads and chemical probes for challenging targets. However, the structural and functional diversity encoded within such libraries is largely...
9.
Hauswirth R, Haase B, Blatter M, Brooks S, Burger D, Drogemuller C, et al.
PLoS Genet
. 2019 Aug;
15(8):e1008321.
PMID: 31374075
[This corrects the article DOI: 10.1371/journal.pgen.1002653.].
10.
Stokes P, Robertson N, Silva A, Estephan T, Trewhella J, Guss J, et al.
Proteins
. 2019 Feb;
87(5):425-429.
PMID: 30788856
Tandem beta zippers are modular complexes formed between repeated linear motifs and tandemly arrayed domains of partner proteins in which β-strands form upon binding. Studies of such complexes, formed by...