Jacqueline L Norris-Drouin
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Explore the profile of Jacqueline L Norris-Drouin including associated specialties, affiliations and a list of published articles.
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24
Citations
199
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Recent Articles
1.
Wellnitz J, Novy B, Novy B, Maxfield T, Zhilinskaya I, Lin S, et al.
bioRxiv
. 2025 Mar;
PMID: 40060514
DNA-encoded library (DEL) technology has become a powerful tool in modern drug discovery. Fully harnessing its potential requires the use of advanced computational methodologies, which are often available only through...
2.
Uguen M, Shell D, Silva M, Deng Y, Li F, Szewczyk M, et al.
Nat Commun
. 2025 Feb;
16(1):1905.
PMID: 39994194
A promising drug target, SETDB1, is a dual methyl-lysine (Kme) reader and methyltransferase implicated in cancer and neurodegenerative disease progression. To help understand the role of the triple Tudor domain...
3.
Johnson R, Graboski A, Li F, Norris-Drouin J, Walton W, Arrowsmith C, et al.
J Med Chem
. 2024 Nov;
67(22):20056-20075.
PMID: 39508435
CHD1 is a chromodomain-helicase DNA-binding protein that preferentially recognizes di- and trimethylated lysine 4 on histone H3 (H3K4me2/3). Genetic studies have established CHD1 as a synthetic lethal target in phosphatase...
4.
Merten E, Sears J, Leisner T, Hardy P, Ghoshal A, Hossain M, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(42):e2409166121.
PMID: 39388272
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has been responsible for numerous large-scale outbreaks in the last twenty years. Currently, there are no FDA-approved therapeutics for any alphavirus infection....
5.
Uguen M, Shell D, Silva M, Deng Y, Li F, Szewczyk M, et al.
bioRxiv
. 2024 Oct;
PMID: 39386588
A promising drug target, SETDB1, is a dual Kme reader and methyltransferase, which has been implicated in cancer and neurodegenerative disease progression. To help understand the role of the triple...
6.
Shell D, Foley C, Wang Q, Smith C, Guduru S, Zeng H, et al.
J Med Chem
. 2023 Oct;
66(20):14133-14149.
PMID: 37782247
Methyl-lysine reader p53 binding protein 1 (53BP1) is a central mediator of DNA break repair and is associated with various human diseases, including cancer. Thus, high-quality 53BP1 chemical probes can...
7.
Sun Z, Waybright J, Beldar S, Chen L, Foley C, Norris-Drouin J, et al.
Adv Sci (Weinh)
. 2023 Sep;
10(25):e2304061.
PMID: 37667836
No abstract available.
8.
Uguen M, Deng Y, Li F, Shell D, Norris-Drouin J, Stashko M, et al.
ACS Chem Biol
. 2023 Aug;
18(8):1846-1853.
PMID: 37556795
Increased expression and hyperactivation of the methyltransferase SET domain bifurcated 1 (SETDB1) are commonly observed in cancer and central nervous system disorders. However, there are currently no reported SETDB1-specific methyltransferase...
9.
Iskandar S, Chiou L, Leisner T, Shell D, Norris-Drouin J, Vaziri C, et al.
J Am Chem Soc
. 2023 Jul;
145(28):15065-15070.
PMID: 37395736
Peptides have historically been underutilized for covalent inhibitor discovery, despite their unique abilities to interact with protein surfaces and interfaces. This is in part due to a lack of methods...
10.
Uguen M, Deng Y, Li F, Shell D, Norris-Drouin J, Stashko M, et al.
bioRxiv
. 2023 May;
PMID: 37214894
Abstract Figure: