Jacqueline J L Jacobs
Overview
Explore the profile of Jacqueline J L Jacobs including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
1597
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0
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Recent Articles
1.
Lam S, van der Lugt R, Cerutti A, Yalcin Z, Thouin A, Simonetta M, et al.
Nat Commun
. 2024 Oct;
15(1):8960.
PMID: 39420004
Appropriate repair of damaged DNA and the suppression of DNA damage responses at telomeres are essential to preserve genome stability. DNA damage response (DDR) signaling consists of cascades of kinase-driven...
2.
Yalcin Z, Lam S, Peuscher M, van der Torre J, Zhu S, Iyengar P, et al.
Nat Commun
. 2024 Jun;
15(1):5032.
PMID: 38866770
Maintenance of genome integrity requires tight control of DNA damage response (DDR) signalling and repair, with phosphorylation and ubiquitination representing key elements. How these events are coordinated to achieve productive...
3.
Yang C, Pataskar A, Feng X, Montenegro Navarro J, Paniagua I, Jacobs J, et al.
Mol Cell
. 2024 May;
84(10):1904-1916.e7.
PMID: 38759626
Many types of human cancers suppress the expression of argininosuccinate synthase 1 (ASS1), a rate-limiting enzyme for arginine production. Although dependency on exogenous arginine can be harnessed by arginine-deprivation therapies,...
4.
Paniagua I, Jacobs J
Bio Protoc
. 2023 Aug;
13(16):e4739.
PMID: 37638291
Maintenance of genome integrity requires efficient and faithful resolution of DNA breaks and DNA replication obstacles. Dysfunctions in any of the processes orchestrating such resolution can lead to chromosomal instability,...
5.
Paniagua I, Jacobs J
Mol Cell
. 2023 Aug;
83(20):3608-3621.
PMID: 37625405
Translesion synthesis (TLS) DNA polymerases were originally described as error-prone enzymes involved in the bypass of DNA lesions. However, extensive research over the past few decades has revealed that these...
6.
Yalcin Z, Koot D, Bezstarosti K, Salas-Lloret D, Bleijerveld O, Boersma V, et al.
Mol Cell Proteomics
. 2023 Apr;
22(6):100548.
PMID: 37059365
Ubiquitination has crucial roles in many cellular processes, and dysregulation of ubiquitin machinery enzymes can result in various forms of pathogenesis. Cells only have a limited set of ubiquitin-conjugating (E2)...
7.
Paniagua I, Tayeh Z, Falcone M, Hernandez Perez S, Cerutti A, Jacobs J
Nat Commun
. 2022 Sep;
13(1):5167.
PMID: 36075897
Protection of stalled replication forks is essential to prevent genome instability, a major driving force of tumorigenesis. Several key regulators of DNA double-stranded break (DSB) repair, including 53BP1 and RIF1,...
8.
de Krijger I, Fohr B, Hernandez Perez S, Vincendeau E, Serrat J, Thouin A, et al.
Nat Commun
. 2021 Sep;
12(1):5421.
PMID: 34521823
MAD2L2 (REV7) plays an important role in DNA double-strand break repair. As a member of the shieldin complex, consisting of MAD2L2, SHLD1, SHLD2 and SHLD3, it controls DNA repair pathway...
9.
de Krijger I, Boersma V, Jacobs J
Trends Cell Biol
. 2021 May;
31(8):686-701.
PMID: 33962851
The HORMA domain protein REV7, also known as MAD2L2, interacts with a variety of proteins and thereby contributes to the establishment of different complexes. With doing so, REV7 impacts a...
10.
de Krijger I, van der Torre J, Peuscher M, Eder M, Jacobs J
Oncogene
. 2020 May;
39(25):4814-4827.
PMID: 32472076
The epigenetic environment plays an important role in DNA damage recognition and repair, both at DNA double-strand breaks and at deprotected telomeres. To increase understanding on how DNA damage responses...