REV7: Jack of Many Trades

Overview

Journal Trends Cell Biol

Specialty Cell Biology

Date 2021 May 8

PMID 33962851

Citations 20

Authors

Inge de Krijger

Vera Boersma

Jacqueline J L Jacobs

Affiliations

Soon will be listed here.

Abstract

The HORMA domain protein REV7, also known as MAD2L2, interacts with a variety of proteins and thereby contributes to the establishment of different complexes. With doing so, REV7 impacts a diverse range of cellular processes and gained increasing interest as more of its activities became uncovered. REV7 has important roles in translesion synthesis and mitotic progression, and acts as a central component in the recently discovered shieldin complex that operates in DNA double-strand break repair. Here we discuss the roles of REV7 in its various complexes, focusing on its activity in genome integrity maintenance. Moreover, we will describe current insights on REV7 structural features that allow it to be such a versatile protein.

Citing Articles

Rev7 promotes non-homologous end-joining by blocking Mre11 nuclease and Rad50's ATPase activities and homologous recombination.

Badugu S, Dhyani K, Thakur M, Muniyappa K Elife. 2024; 13.

PMID: 39630591 PMC: 11616998. DOI: 10.7554/eLife.96933.

MAD2L2 Dimerization Is Not Essential for Mitotic Regulation.

Barda N, Ayiku P, Bar-On A, Movshovitz S, Listovsky T Int J Mol Sci. 2024; 25(21).

PMID: 39519037 PMC: 11545987. DOI: 10.3390/ijms252111485.

Phenotypic landscape of a fungal meningitis pathogen reveals its unique biology.

Boucher M, Banerjee S, Joshi M, Wei A, Huang M, Lei S bioRxiv. 2024; .

PMID: 39484549 PMC: 11526942. DOI: 10.1101/2024.10.22.619677.

Probing hot spots of protein-protein interactions mediated by the safety-belt region of REV7.

Dash R, Arianna G, Patel S, Rizzo A, Harrahill N, Korzhnev D Structure. 2024; 32(11):2134-2146.e3.

PMID: 39366370 PMC: 11631137. DOI: 10.1016/j.str.2024.09.007.

REV7-p53 interaction inhibits ATM-mediated DNA damage signaling.

Biller M, Kabir S, Boado C, Nipper S, Saffa A, Tal A Cell Cycle. 2024; 23(4):339-352.

PMID: 38557443 PMC: 11174130. DOI: 10.1080/15384101.2024.2333227.

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