Inge de Krijger
Overview
Explore the profile of Inge de Krijger including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
795
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0
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Recent Articles
1.
Yalcin Z, Lam S, Peuscher M, van der Torre J, Zhu S, Iyengar P, et al.
Nat Commun
. 2024 Jun;
15(1):5032.
PMID: 38866770
Maintenance of genome integrity requires tight control of DNA damage response (DDR) signalling and repair, with phosphorylation and ubiquitination representing key elements. How these events are coordinated to achieve productive...
2.
de Krijger I, Fohr B, Hernandez Perez S, Vincendeau E, Serrat J, Thouin A, et al.
Nat Commun
. 2021 Sep;
12(1):5421.
PMID: 34521823
MAD2L2 (REV7) plays an important role in DNA double-strand break repair. As a member of the shieldin complex, consisting of MAD2L2, SHLD1, SHLD2 and SHLD3, it controls DNA repair pathway...
3.
de Krijger I, Boersma V, Jacobs J
Trends Cell Biol
. 2021 May;
31(8):686-701.
PMID: 33962851
The HORMA domain protein REV7, also known as MAD2L2, interacts with a variety of proteins and thereby contributes to the establishment of different complexes. With doing so, REV7 impacts a...
4.
de Krijger I, van der Torre J, Peuscher M, Eder M, Jacobs J
Oncogene
. 2020 May;
39(25):4814-4827.
PMID: 32472076
The epigenetic environment plays an important role in DNA damage recognition and repair, both at DNA double-strand breaks and at deprotected telomeres. To increase understanding on how DNA damage responses...
5.
Dev H, Chiang T, Lescale C, de Krijger I, Martin A, Pilger D, et al.
Nat Cell Biol
. 2018 Jul;
20(8):954-965.
PMID: 30022119
BRCA1 deficiencies cause breast, ovarian, prostate and other cancers, and render tumours hypersensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. To understand the resistance mechanisms, we conducted whole-genome CRISPR-Cas9 synthetic-viability/resistance screens in...
6.
Barazas M, Annunziato S, Pettitt S, de Krijger I, Ghezraoui H, Roobol S, et al.
Cell Rep
. 2018 May;
23(7):2107-2118.
PMID: 29768208
Selective elimination of BRCA1-deficient cells by inhibitors of poly(ADP-ribose) polymerase (PARP) is a prime example of the concept of synthetic lethality in cancer therapy. This interaction is counteracted by the...
7.
Simonetta M, de Krijger I, Serrat J, Moatti N, Fortunato D, Hoekman L, et al.
Cell Cycle
. 2017 Nov;
17(1):124-136.
PMID: 29160738
The main pathways for the repair of DNA double strand breaks (DSBs) are non-homologous end-joining (NHEJ) and homologous recombination directed repair (HDR). These operate mutually exclusive and are activated by...
8.
Luijsterburg M, de Krijger I, Wiegant W, Shah R, Smeenk G, de Groot A, et al.
Mol Cell
. 2016 Feb;
61(4):547-562.
PMID: 26895424
The response to DNA double-strand breaks (DSBs) requires alterations in chromatin structure to promote the assembly of repair complexes on broken chromosomes. Non-homologous end-joining (NHEJ) is the dominant DSB repair...
9.
Fritsch R, de Krijger I, Fritsch K, George R, Reason B, Kumar M, et al.
Cell
. 2013 May;
153(5):1050-63.
PMID: 23706742
RAS proteins are important direct activators of p110α, p110γ, and p110δ type I phosphoinositide 3-kinases (PI3Ks), interacting via an amino-terminal RAS-binding domain (RBD). Here, we investigate the regulation of the...
10.
Mekenkamp L, Tol J, Dijkstra J, de Krijger I, Vink-Borger M, van Vliet S, et al.
BMC Cancer
. 2012 Jul;
12:292.
PMID: 22804917
Background: KRAS mutation is a negative predictive factor for treatment with anti-epidermal growth factor receptor (EGFR) antibodies in metastatic colorectal cancer (mCRC). Novel predictive markers are required to further improve...