Liesbeth Hoekman
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Explore the profile of Liesbeth Hoekman including associated specialties, affiliations and a list of published articles.
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27
Citations
297
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Recent Articles
1.
Gobel C, Niccolai R, de Groot M, Jayachandran J, Traets J, Kloosterman D, et al.
Blood
. 2025 Jan;
PMID: 39792929
Differentiation of antigen-activated B cells into pro-proliferative germinal center (GC) B cells depends on the activity of the transcription factors MYC and BCL6, and the epigenetic writers DOT1L and EZH2....
2.
Ramalho S, Alkan F, Prekovic S, Jastrzebski K, Barbera E, Hoekman L, et al.
Sci Adv
. 2025 Jan;
11(2):eadn9750.
PMID: 39772672
Intestinal stem cells (ISCs) face the challenge of integrating metabolic demands with unique regenerative functions. Studies have shown an intricate interplay between metabolism and stem cell capacity; however, it is...
3.
Casagrande Raffi G, Chen J, Feng X, Chen Z, Lieftink C, Deng S, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(52):e2417724121.
PMID: 39693343
Drugs that eliminate senescent cells, senolytics, can be powerful when combined with prosenescence cancer therapies. Using a CRISPR/Cas9-based genetic screen, we identify here SLC25A23 as a vulnerability of senescent cancer...
4.
Dopler A, Alkan F, Malka Y, van der Kammen R, Hoefakker K, Taranto D, et al.
Cell
. 2024 Oct;
187(24):6981-6993.e23.
PMID: 39437780
Inflammatory cytokines are pivotal to immune responses. Upon cytokine exposure, cells enter an "alert state" that enhances their visibility to the immune system. Here, we identified an alert-state subpopulation of...
5.
Shah R, Aslam M, Spanjaard A, de Groot D, Zurcher L, Altelaar M, et al.
PNAS Nexus
. 2024 Jul;
3(7):pgae242.
PMID: 38957451
The Fanconi anemia (FA) repair pathway governs repair of highly genotoxic DNA interstrand crosslinks (ICLs) and relies on translesion synthesis (TLS). TLS is facilitated by REV1 or site-specific monoubiquitination of...
6.
Yalcin Z, Lam S, Peuscher M, van der Torre J, Zhu S, Iyengar P, et al.
Nat Commun
. 2024 Jun;
15(1):5032.
PMID: 38866770
Maintenance of genome integrity requires tight control of DNA damage response (DDR) signalling and repair, with phosphorylation and ubiquitination representing key elements. How these events are coordinated to achieve productive...
7.
Wang W, Atherton P, Kreft M, Te Molder L, van der Poel S, Hoekman L, et al.
J Cell Sci
. 2024 Apr;
137(9).
PMID: 38587458
Talin (herein referring collectively to talin 1 and 2) couples the actomyosin cytoskeleton to integrins and transmits tension to the extracellular matrix. Talin also interacts with numerous additional proteins capable...
8.
Lin C, Levy P, Alflen A, Apriamashvili G, Ligtenberg M, Vredevoogd D, et al.
Cancer Cell
. 2024 Mar;
42(4):623-645.e10.
PMID: 38490212
Genes limiting T cell antitumor activity may serve as therapeutic targets. It has not been systematically studied whether there are regulators that uniquely or broadly contribute to T cell fitness....
9.
van Breugel M, van Kruijsbergen I, Mittal C, Lieftink C, Brouwer I, van den Brand T, et al.
Mol Cell
. 2023 Nov;
83(23):4205-4221.e9.
PMID: 37995691
Transcription of tRNA genes by RNA polymerase III (RNAPIII) is tuned by signaling cascades. The emerging notion of differential tRNA gene regulation implies the existence of additional regulatory mechanisms. However,...
10.
Prekovic S, Chalkiadakis T, Roest M, Roden D, Lutz C, Schuurman K, et al.
EMBO Mol Med
. 2023 Oct;
15(12):e17737.
PMID: 37902007
Glucocorticoid receptor (GR) is a transcription factor that plays a crucial role in cancer biology. In this study, we utilized an in silico-designed GR activity signature to demonstrate that GR...