Jacob T Mitchell
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Explore the profile of Jacob T Mitchell including associated specialties, affiliations and a list of published articles.
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9
Citations
64
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Recent Articles
1.
Montagne J, Mitchell J, Tandurella J, Christenson E, Danilova L, Deshpande A, et al.
iScience
. 2025 Jan;
28(1):111569.
PMID: 39811671
Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy requires therapeutic combinations that induce quality T cells. Tumor microenvironment (TME) analysis following therapeutic interventions can identify response mechanisms, informing design of effective combinations....
2.
Loveless I, Kemp S, Hartway K, Mitchell J, Wu Y, Zwernik S, et al.
Clin Cancer Res
. 2024 Dec;
31(4):756-772.
PMID: 39636224
Purpose: Pancreatic ductal adenocarcinoma (PDAC) patients with tumors enriched for the basal-like molecular subtype exhibit enhanced resistance to standard-of-care treatments and have significantly worse overall survival compared with patients with...
3.
Bramel E, Espinoza Camejo W, Creamer T, Restrepo L, Saqib M, Bagirzadeh R, et al.
Nat Cardiovasc Res
. 2024 Nov;
3(12):1468-1481.
PMID: 39567770
Loeys-Dietz syndrome (LDS) is a connective tissue disorder caused by mutations that decrease transforming growth factor-β signaling. LDS-causing mutations increase the risk of aneurysm throughout the arterial tree, yet the...
4.
Bell A, Mitchell J, Kiemen A, Lyman M, Fujikura K, Lee J, et al.
Cell Syst
. 2024 Aug;
15(8):753-769.e5.
PMID: 39116880
This study introduces a new imaging, spatial transcriptomics (ST), and single-cell RNA-sequencing integration pipeline to characterize neoplastic cell state transitions during tumorigenesis. We applied a semi-supervised analysis pipeline to examine...
5.
Gross N, Zhang Z, Mitchell J, Charmsaz S, Hernandez A, Coyne E, et al.
JCI Insight
. 2024 Aug;
9(18).
PMID: 39106104
Pancreatic ductal adenocarcinoma (PDAC) is highly lethal and resistant to immunotherapy. Although immune recognition can be enhanced with immunomodulatory agents including checkpoint inhibitors and vaccines, few patients experience clinical efficacy...
6.
Bramel E, Espinoza Camejo W, Creamer T, Restrepo L, Saqib M, Bagirzadeh R, et al.
Res Sq
. 2024 Jun;
PMID: 38883722
Loeys-Dietz syndrome (LDS) is an aneurysm disorder caused by mutations that decrease transforming growth factor-β (TGF-β) signaling. Although aneurysms develop throughout the arterial tree, the aortic root is a site...
7.
Guinn S, Kinny-Koster B, Tandurella J, Mitchell J, Sidiropoulos D, Loth M, et al.
Cancer Res
. 2024 Apr;
84(9):1517-1533.
PMID: 38587552
Significance: Adaptation of transfer learning to relate human single-cell RNA sequencing data to organoid-CAF cocultures facilitates discovery of human pancreatic cancer intercellular interactions and uncovers cross-talk between CAFs and tumor...
8.
Huff A, Longway G, Mitchell J, Andaloori L, Davis-Marcisak E, Chen F, et al.
JCI Insight
. 2023 Dec;
8(23).
PMID: 38063199
Personalized cancer vaccines aim to activate and expand cytotoxic antitumor CD8+ T cells to recognize and kill tumor cells. However, the role of CD4+ T cell activation in the clinical...
9.
Johnson J, Tsang A, Mitchell J, Zhou D, Bowden J, Davis-Marcisak E, et al.
Nat Protoc
. 2023 Nov;
18(12):3690-3731.
PMID: 37989764
Non-negative matrix factorization (NMF) is an unsupervised learning method well suited to high-throughput biology. However, inferring biological processes from an NMF result still requires additional post hoc statistics and annotation...
10.
Li K, Tandurella J, Gai J, Zhu Q, Lim S, Thomas 2nd D, et al.
Cancer Cell
. 2022 Oct;
40(11):1374-1391.e7.
PMID: 36306792
Successful pancreatic ductal adenocarcinoma (PDAC) immunotherapy necessitates optimization and maintenance of activated effector T cells (Teff). We prospectively collected and applied multi-omic analyses to paired pre- and post-treatment PDAC specimens...