Jacob Lauwring Andersen
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Explore the profile of Jacob Lauwring Andersen including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
154
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Recent Articles
1.
Fruergaard M, Nielsen C, Kjeldsen C, Iversen L, Andersen J, Nissen P
Life Sci Alliance
. 2023 Feb;
6(5).
PMID: 36806093
The p90 ribosomal S6 kinases (RSKs) contain two distinct catalytic kinase domains, the N-terminal and C-terminal kinase domains (NTKD and CTKD, respectively). The activation of CTKD is regulated by phosphorylation...
2.
Basse Hansen S, Dyla M, Neumann C, Quistgaard E, Andersen J, Kjaergaard M, et al.
J Mol Biol
. 2021 May;
433(16):167015.
PMID: 33933469
Many bacteria export intracellular calcium using active transporters homologous to the sarco/endoplasmic reticulum Ca-ATPase (SERCA). Here we present three crystal structures of Ca-ATPase 1 from Listeria monocytogenes (LMCA1). Structures with...
3.
Sitsel A, De Raeymaecker J, Drachmann N, Derua R, Smaardijk S, Andersen J, et al.
EMBO J
. 2019 Feb;
38(5).
PMID: 30777856
The sarcoplasmic/endoplasmic reticulum Ca-ATPase 2a (SERCA2a) performs active reuptake of cytoplasmic Ca and is a major regulator of cardiac muscle contractility. Dysfunction or dysregulation of SERCA2a is associated with heart...
4.
Sorensen T, Hjorth-Jensen S, Oksanen E, Andersen J, Olesen C, Moller J, et al.
Acta Crystallogr D Struct Biol
. 2019 Jan;
74(Pt 12):1208-1218.
PMID: 30605135
Neutron macromolecular crystallography (NMX) has the potential to provide the experimental input to address unresolved aspects of transport mechanisms and protonation in membrane proteins. However, despite this clear scientific motivation,...
5.
Andersen J, Gesser B, Funder E, Nielsen C, Gotfred-Rasmussen H, Rasmussen M, et al.
Nat Commun
. 2018 Oct;
9(1):4344.
PMID: 30341347
Dimethyl fumarate (DMF) has been applied for decades in the treatment of psoriasis and now also multiple sclerosis. However, the mechanism of action has remained obscure and involves high dose...
6.
Guo J, Jiang R, Andersen J, Esmann M, Fedosova N
FEBS J
. 2018 Apr;
285(12):2292-2305.
PMID: 29688626
The information obtained from crystallized complexes of the Na ,K -ATPase with cardiotonic steroids (CTS) is not sufficient to explain differences in the inhibitory properties of CTS such as stereoselectivity...
7.
Dyla M, Terry D, Kjaergaard M, Sorensen T, Andersen J, Andersen J, et al.
Nature
. 2017 Nov;
551(7680):346-351.
PMID: 29144454
Phosphorylation-type (P-type) ATPases are ubiquitous primary transporters that pump cations across cell membranes through the formation and breakdown of a phosphoenzyme intermediate. Structural investigations suggest that the transport mechanism is...
8.
Januliene D, Andersen J, Nielsen J, Quistgaard E, Hansen M, Strandbygaard D, et al.
Structure
. 2017 Nov;
25(12):1809-1819.e3.
PMID: 29107483
Sortilin is a neuronal receptor involved in transmembrane signaling, endocytosis, and intracellular sorting of proteins. It cycles through a number of cellular compartments where it encounters various acidic conditions. The...
9.
Andersen J, Lindberg S, Langgard M, Maltas P, Biilmann Ronn L, Bundgaard C, et al.
Bioorg Med Chem Lett
. 2017 May;
27(11):2629-2633.
PMID: 28462834
Using fragment based and structure based drug discovery strategies a series of novel Sortilin inhibitors has been identified. The inhibitors are based on the N-substituted 1,2,3-triazol-4-one/ol heterocyclic template. X-ray crystallography...
10.
Dyla M, Andersen J, Kjaergaard M, Birkedal V, Terry D, Altman R, et al.
Bioconjug Chem
. 2016 Aug;
27(9):2176-87.
PMID: 27501274
Approximately 30% of the ATP generated in the living cell is utilized by P-type ATPase primary active transporters to generate and maintain electrochemical gradients across biological membranes. P-type ATPases undergo...