Jacob E Lazarus
Overview
Explore the profile of Jacob E Lazarus including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
31
Citations
814
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
21.
Thom C, Traxler E, Khandros E, Nickas J, Zhou O, Lazarus J, et al.
Dev Cell
. 2014 Sep;
30(6):688-700.
PMID: 25241935
TRIM58 is an E3 ubiquitin ligase superfamily member implicated by genome-wide association studies to regulate human erythrocyte traits. Here, we show that Trim58 expression is induced during late erythropoiesis and...
22.
Ayloo S, Lazarus J, Dodda A, Tokito M, Ostap E, Holzbaur E
Nat Commun
. 2014 Sep;
5:4807.
PMID: 25185702
Dynactin is an essential cofactor for most cellular functions of the microtubule motor cytoplasmic dynein, but the mechanism by which dynactin activates dynein remains unclear. Here we use single molecule...
23.
Perlson E, Hendricks A, Lazarus J, Ben-Yaakov K, Gradus T, Tokito M, et al.
J Biol Chem
. 2013 Aug;
288(39):27812-24.
PMID: 23960070
Cytoplasmic dynein is well characterized as an organelle motor, but dynein also acts to tether and stabilize dynamic microtubule plus-ends in vitro. Here we identify a novel and direct interaction...
24.
Moughamian A, Osborn G, Lazarus J, Maday S, Holzbaur E
J Neurosci
. 2013 Aug;
33(32):13190-203.
PMID: 23926272
Long-range retrograde axonal transport in neurons is driven exclusively by the microtubule motor cytoplasmic dynein. The efficient initiation of dynein-mediated transport from the distal axon is critical for normal neuronal...
25.
Lazarus J, Moughamian A, Tokito M, Holzbaur E
PLoS Biol
. 2013 Jul;
11(7):e1001611.
PMID: 23874158
Regulation of microtubule dynamics in neurons is critical, as defects in the microtubule-based transport of axonal organelles lead to neurodegenerative disease. The microtubule motor cytoplasmic dynein and its partner complex...
26.
Zhang J, Twelvetrees A, Lazarus J, Blasier K, Yao X, Inamdar N, et al.
Cytoskeleton (Hoboken)
. 2013 Mar;
70(4):215-27.
PMID: 23475693
Cytoplasmic dynein plays important roles in mitosis and the intracellular transport of organelles, proteins, and mRNAs. Dynein function is particularly critical for survival of neurons, as mutations in dynein are...
27.
Hendricks A, Lazarus J, Perlson E, Gardner M, Odde D, Goldman Y, et al.
Curr Biol
. 2012 Mar;
22(7):632-7.
PMID: 22445300
Microtubules undergo alternating periods of growth and shortening, known as dynamic instability. These dynamics allow microtubule plus ends to explore cellular space. The "search and capture" model posits that selective...
28.
Hendricks A, Lazarus J, Holzbaur E
Nat Cell Biol
. 2010 Nov;
12(12):1126-8.
PMID: 21102436
Cytoplasmic dynein drives vesicular transport from the periphery to the cell body of neurons. Missense mutations in the dynein tail domain cause neurodegenerative disease in mouse models. new data on...
29.
Dixit R, Barnett B, Lazarus J, Tokito M, Goldman Y, Holzbaur E
Proc Natl Acad Sci U S A
. 2009 Jan;
106(2):492-7.
PMID: 19126680
Microtubules are polarized polymers that exhibit dynamic instability, with alternating phases of elongation and shortening, particularly at the more dynamic plus-end. Microtubule plus-end tracking proteins (+TIPs) localize to and track...
30.
Finkielstain G, Forcinito P, Lui J, Barnes K, Marino R, Makaroun S, et al.
Endocrinology
. 2008 Nov;
150(4):1791-800.
PMID: 19036884
Mammalian somatic growth is rapid in early postnatal life but then slows and eventually ceases in multiple tissues. We hypothesized that there exists a postnatal gene expression program that is...