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Jacob Croft

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Recent Articles
1.
Croft J, Grajeda B, Gao L, Abou-Fadel J, Badr A, Sheng V, et al.
Diagnostics (Basel) . 2024 Sep; 14(17). PMID: 39272679
Cerebral cavernous malformations (CCMs) are abnormal expansions of brain capillaries that increase the risk of hemorrhagic strokes, with CCM1 mutations responsible for about 50% of familial cases. The disorder can...
2.
Croft J, Sandoval D, Cistola D, Zhang J
Metab Brain Dis . 2024 May; 39(5):885-893. PMID: 38795261
Cerebral cavernous malformations (CCMs) are abnormal clusters of capillaries in the nervous system. This pilot study analyzed the cardiometabolic health status of individuals with familial CCMs caused by a rare...
3.
Sanchez N, Harvey C, Vincent D, Croft J, Zhang J
Transl Breast Cancer Res . 2024 May; 4:21. PMID: 38751477
Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer-related death in women, accounting for approximately 30% of all new cancer cases. The prognosis of...
4.
Croft J, Grajeda B, Aguirre L, Abou-Fadel J, Ellis C, Estevao I, et al.
Int J Mol Sci . 2024 May; 25(9). PMID: 38731959
Cerebral cavernous malformations (CCMs) are a neurological disorder characterized by enlarged intracranial capillaries in the brain, increasing the susceptibility to hemorrhagic strokes, a major cause of death and disability worldwide....
5.
Croft J, Gao L, Sheng V, Zhang J
Front Biosci (Landmark Ed) . 2024 Feb; 29(2):75. PMID: 38420834
Background: Cerebral Cavernous Malformations (CCMs) are brain vascular abnormalities associated with an increased risk of hemorrhagic strokes. Familial CCMs result from autosomal dominant inheritance involving three genes: (), (), and...
6.
Croft J, Sandoval D, Cistola D, Zhang J
Res Sq . 2023 Sep; PMID: 37674713
Introduction: Cerebral cavernous malformations (CCMs) are abnormal clusters of capillaries in the nervous system. This pilot study analyzed the cardiometabolic health status of individuals with familial CCMs caused by a...
7.
Croft J, Sandoval D, Cistola D, Zhang J
medRxiv . 2023 Aug; PMID: 37645828
Introduction: Cerebral cavernous malformations (CCMs) are abnormal clusters of capillaries in the nervous system. This pilot study analyzed the cardiometabolic health status of individuals with familial CCMs caused by a...
8.
Gnanasekaran R, Aickareth J, Hawwar M, Sanchez N, Croft J, Zhang J
J Pers Med . 2023 May; 13(5). PMID: 37240921
Cerebral cavernous malformations (CCMs) arise when capillaries within the brain enlarge abnormally, causing the blood-brain barrier (BBB) to break down. The BBB serves as a sophisticated interface that controls molecular...
9.
Zhang J, Croft J, Le A
J Pers Med . 2023 Apr; 13(4). PMID: 37109059
Cerebral cavernous malformations (CCMs) are abnormally dilated intracranial capillaries that form cerebrovascular lesions with a high risk of hemorrhagic stroke. Recently, several somatic "activating" gain-of-function (GOF) point mutations in PIK3CA...
10.
Abou-Fadel J, Reid V, Le A, Croft J, Zhang J
Diagnostics (Basel) . 2023 Mar; 13(6). PMID: 36980321
Liver cancer, comprising hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), is a leading cause of cancer-related deaths worldwide. The liver is a primary metabolic organ for progesterone (PRG) and PRG exerts...