Jack D Keene
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Explore the profile of Jack D Keene including associated specialties, affiliations and a list of published articles.
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53
Citations
4422
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Recent Articles
1.
Ruthig V, Hatkevich T, Hardy J, Friedersdorf M, Mayere C, Nef S, et al.
PLoS Genet
. 2023 Mar;
19(3):e1010656.
PMID: 36857387
DND1 is essential to maintain germ cell identity. Loss of Dnd1 function results in germ cell differentiation to teratomas in some inbred strains of mice or to somatic fates in...
2.
Ruthig V, Yokonishi T, Friedersdorf M, Batchvarova S, Hardy J, Garness J, et al.
Biol Reprod
. 2021 Jan;
104(4):861-874.
PMID: 33394034
In vertebrates, the RNA-binding protein (RBP) dead end 1 (DND1) is essential for primordial germ cell (PGC) survival and maintenance of cell identity. In multiple species, Dnd1 loss or mutation...
3.
Ruthig V, Friedersdorf M, Garness J, Munger S, Bunce C, Keene J, et al.
Development
. 2019 Jun;
146(19).
PMID: 31253634
The adult spermatogonial stem cell population arises from pluripotent primordial germ cells (PGCs) that enter the fetal testis around embryonic day (E)10.5. PGCs undergo rapid mitotic proliferation, then enter prolonged...
4.
Bisogno L, Friedersdorf M, Keene J
iScience
. 2018 Sep;
4:97-108.
PMID: 30240757
Epithelial-to-mesenchymal transition (EMT) is integral to cancer progression, with considerable evidence that EMT has multiple intermediary stages. Understanding the mechanisms of this stepwise activation is of great interest. We recreated...
5.
Wang S, Jung Y, Hyun J, Friedersdorf M, Oh S, Kim J, et al.
Cell Physiol Biochem
. 2018 Jul;
48(3):1215-1229.
PMID: 30045014
Background/aims: Myofibroblasts (MF) derived from quiescent nonfibrogenic hepatic stellate cells (HSC) are the major sources of fibrous matrix in cirrhosis. Because many factors interact to regulate expansion and regression of...
6.
Bisogno L, Keene J
Methods
. 2017 May;
126:193-200.
PMID: 28529064
Post-transcriptional regulation of gene expression by RNA binding proteins (RBPs) and non-coding RNAs plays an important role in global gene expression. Many post-transcriptional regulators are misexpressed and misregulated in cancers,...
7.
8.
Nicholson C, Friedersdorf M, Bisogno L, Keene J
Methods
. 2016 Nov;
118-119:16-23.
PMID: 27840290
Post-transcriptional processes orchestrate gene expression through dynamic protein-RNA interactions. These interactions occur at specific sites determined by RNA sequence, secondary structure, or nucleotide modifications. Methods have been developed either to...
9.
Nicholson C, Friedersdorf M, Keene J
RNA
. 2016 Oct;
23(1):32-46.
PMID: 27742911
RNA-binding proteins (RBPs) and noncoding RNAs orchestrate post-transcriptional processes through the recognition of specific sites on targeted transcripts. Thus, understanding the connection between binding to specific sites and active regulation...
10.
Smola M, Christy T, Inoue K, Nicholson C, Friedersdorf M, Keene J, et al.
Proc Natl Acad Sci U S A
. 2016 Sep;
113(37):10322-7.
PMID: 27578869
The 18-kb Xist long noncoding RNA (lncRNA) is essential for X-chromosome inactivation during female eutherian mammalian development. Global structural architecture, cell-induced conformational changes, and protein-RNA interactions within Xist are poorly...