J W Darnowski
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Explore the profile of J W Darnowski including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
162
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Recent Articles
1.
Ribizzi I, Darnowski J, Goulette F, Akhtar M, Chatterjee D, Calabresi P
Bone Marrow Transplant
. 2002 Mar;
29(4):313-9.
PMID: 11896428
Taurolidine has been shown to have remarkable cytotoxic activity against selected human tumor cells at concentrations that spare normal cells. In this study we have extended this observation and assessed...
2.
Calabresi P, Goulette F, Darnowski J
Cancer Res
. 2001 Sep;
61(18):6816-21.
PMID: 11559556
Bis-(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)methane (taurolidine) is a synthetic broad-spectrum antibiotic that reacts with bacterial cell membrane components to prevent adhesion to epithelial cell surfaces. Reflecting the key role of adhesion in the growth...
3.
Ribizzi I, Darnowski J, Goulette F, Sertoli M, Calabresi P
Leuk Res
. 2000 Apr;
24(6):519-25.
PMID: 10781687
Amifostine (AMF), a phosphorylated aminothiol, has been used to treat myelodysplastic syndrome (MDS), where it produces a stimulatory effect on hematopoiesis in bone marrow. To determine if AMF also produced...
4.
Whartenby K, Darnowski J, Freeman S, Yurasha K, Calabresi P
Cancer Gene Ther
. 1999 Oct;
6(5):402-8.
PMID: 10505850
The herpes simplex virus thymidine kinase (HSV-TK) gene is being developed in the treatment of many different types of tumors. The HSV-TK gene sensitizes tumor cells to the antiviral drug...
5.
Pizzorno G, Yee L, Burtness B, Marsh J, Darnowski J, Chu M, et al.
Clin Cancer Res
. 1998 Jun;
4(5):1165-75.
PMID: 9607574
Benzylacyclouridine (BAU, IND 039655) is a potent and specific inhibitor of uridine phosphorylase (UrdPase; EC 2.4.2.3). This enzyme plays a major role in regulating uridine homeostasis and also catalyzes the...
6.
Darnowski J, Davol P, Goulette F
Biochem Pharmacol
. 1997 Feb;
53(4):571-80.
PMID: 9105409
We reported that 3'-azidothymidine-3'-deoxythymidine (AZT) plus 5-fluorouracil or methotrexate produces additive cytotoxicity in HCT-8 cells: a reflection of increased AZT metabolism when de novo thymidylate (dTMP) synthesis was inhibited. We...
7.
Rana K, Darnowski J, Strayer A, Dudley M
Antimicrob Agents Chemother
. 1996 Aug;
40(8):1945-7.
PMID: 8843311
Zidovudine (ZDV) and clarithromycin (CLR) are often used simultaneously in the management of patients with AIDS. While pharmacokinetic studies show decreased absorption of ZDV when it is administered with CLR,...
8.
Davol P, Goulette F, Frackelton Jr A, Darnowski J
Cancer Res
. 1996 Jun;
56(11):2522-6.
PMID: 8653690
G3361/CP cells, a cisplatin (CDDP)-resistant subclone of the human melanoma cell line G3361, overexpress wild-type p53 protein and demonstrate an increase in the percentage of cells in G0--G1 arrest compared...
9.
Sharma M, Jain R, Ionescu E, Darnowski J
Bioconjug Chem
. 1995 Sep;
6(5):536-40.
PMID: 8974451
We have previously reported that 3'-azido-3'-deoxythymidine (AZT) can possess significant antineoplastic activity in vitro and in vivo when combined with agents which inhibit de novo thymidylate synthesis. Under these conditions...
10.
Darnowski J, Goulette F
Biochem Pharmacol
. 1994 Nov;
48(9):1797-805.
PMID: 7980649
We have reported that 3'-azido-3'-deoxythymidine (AZT) possesses significant cytotoxicity in human tumor models when combined with agents that inhibit de novo thymidylate (dTMP) synthesis, such as 5-fluorouracil (FUra) and methotrexate...