F A Goulette
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Explore the profile of F A Goulette including associated specialties, affiliations and a list of published articles.
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9
Citations
71
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Recent Articles
1.
Ribizzi I, Darnowski J, Goulette F, Akhtar M, Chatterjee D, Calabresi P
Bone Marrow Transplant
. 2002 Mar;
29(4):313-9.
PMID: 11896428
Taurolidine has been shown to have remarkable cytotoxic activity against selected human tumor cells at concentrations that spare normal cells. In this study we have extended this observation and assessed...
2.
Calabresi P, Goulette F, Darnowski J
Cancer Res
. 2001 Sep;
61(18):6816-21.
PMID: 11559556
Bis-(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)methane (taurolidine) is a synthetic broad-spectrum antibiotic that reacts with bacterial cell membrane components to prevent adhesion to epithelial cell surfaces. Reflecting the key role of adhesion in the growth...
3.
Ribizzi I, Darnowski J, Goulette F, Sertoli M, Calabresi P
Leuk Res
. 2000 Apr;
24(6):519-25.
PMID: 10781687
Amifostine (AMF), a phosphorylated aminothiol, has been used to treat myelodysplastic syndrome (MDS), where it produces a stimulatory effect on hematopoiesis in bone marrow. To determine if AMF also produced...
4.
Darnowski J, Davol P, Goulette F
Biochem Pharmacol
. 1997 Feb;
53(4):571-80.
PMID: 9105409
We reported that 3'-azidothymidine-3'-deoxythymidine (AZT) plus 5-fluorouracil or methotrexate produces additive cytotoxicity in HCT-8 cells: a reflection of increased AZT metabolism when de novo thymidylate (dTMP) synthesis was inhibited. We...
5.
Davol P, Goulette F, Frackelton Jr A, Darnowski J
Cancer Res
. 1996 Jun;
56(11):2522-6.
PMID: 8653690
G3361/CP cells, a cisplatin (CDDP)-resistant subclone of the human melanoma cell line G3361, overexpress wild-type p53 protein and demonstrate an increase in the percentage of cells in G0--G1 arrest compared...
6.
Darnowski J, Goulette F
Biochem Pharmacol
. 1994 Nov;
48(9):1797-805.
PMID: 7980649
We have reported that 3'-azido-3'-deoxythymidine (AZT) possesses significant cytotoxicity in human tumor models when combined with agents that inhibit de novo thymidylate (dTMP) synthesis, such as 5-fluorouracil (FUra) and methotrexate...
7.
Tosi P, Calabresi P, Goulette F, Renaud C, Darnowski J
Cancer Res
. 1992 Aug;
52(15):4069-73.
PMID: 1638518
We have reported that 5-fluorouracil can increase the cytotoxic and antineoplastic activity of 3'-azido-3'-deoxythymidine (AZT). To further evaluate the antineoplastic utility of AZT we now have assessed its effect in...
8.
Darnowski J, Handschumacher R, Wiegand R, Goulette F, Calabresi P
Biochem Pharmacol
. 1991 Jun;
41(12):2031-6.
PMID: 2039551
The concentration of uridine (Urd) in murine tissues appears to be controlled by Urd catabolism, concentrative Urd transport, and the non-concentrative, facilitated diffusion of Urd. Previous reports document the tissue-specific...
9.
Brunetti I, Falcone A, Calabresi P, Goulette F, Darnowski J
Cancer Res
. 1990 Jul;
50(13):4026-31.
PMID: 2354452
Preliminary in vitro studies suggest that the combination of 5-fluorouracil (FUra) and 3'-azido-3'-deoxythymidine (AZT) is more cytotoxic than either agent alone. Therefore, a biochemical and therapeutic evaluation of this combination...