J S Driscoll
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Explore the profile of J S Driscoll including associated specialties, affiliations and a list of published articles.
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Articles
69
Citations
503
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Recent Articles
1.
McCormack J, Marquez V, Liu P, Vistica D, Driscoll J
Biochem Pharmacol
. 2010 Mar;
29(5):830-2.
PMID: 20227965
No abstract available.
2.
Siddiqui M, Driscoll J, Abushanab E, Kelley J, Barchi Jr J, Marquez V
Nucleosides Nucleotides Nucleic Acids
. 2000 Apr;
19(1-2):1-12.
PMID: 10772699
An alternative method to conduct a Barton-McCombie deoxygenation in nucleosides is described. The utility of the procedure is limited to structures with an electronegative substituent, particularly fluorine, in the beta-position...
3.
Buckheit Jr R, Russell J, Pallansch L, Driscoll J
Antivir Chem Chemother
. 1999 Aug;
10(3):115-9.
PMID: 10431610
2'-Fluoro-2'3'-dideoxyarabinosyladenine (F-ddA), a nucleoside reverse transcriptase inhibitor of human immunodeficiency virus (HIV) replication, is currently being evaluated in clinical trials. Future monotherapy for the treatment of HIV is unlikely owing...
4.
AHLUWALIA G, Dedrick R, Driscoll J, Morrison P, Gao W, Johns D
Drug Metab Dispos
. 1997 Jul;
25(7):893-6.
PMID: 9224785
Measurement of intracellular drug levels in cell culture systems can be of predictive value in establishing rational clinical dosage schedules. Such in vitro measurements carried out with anti-HIV agents of...
5.
Tanaka M, Srinivas R, Ueno T, Kavlick M, Hui F, Fridland A, et al.
Antimicrob Agents Chemother
. 1997 Jun;
41(6):1313-8.
PMID: 9174190
2'-beta-Fluoro-2',3'-dideoxyadenosine (F-ddA) is an acid-stable purine dideoxynucleoside analog active against a wide spectrum of human immunodeficiency virus type 1 (HIV-1) and HIV-2 strains in vitro. F-ddA is presently undergoing a...
6.
Ruxrungtham K, Boone E, Ford Jr H, Driscoll J, Davey Jr R, Lane H
Antimicrob Agents Chemother
. 1996 Oct;
40(10):2369-74.
PMID: 8891146
A new antiretroviral agent, 2'-beta-fluoro-2',3'-dideoxyadenosine (FddA), is an acid-stable compound whose triphosphate form is a potent reverse transcriptase inhibitor with in vitro anti-human immunodeficiency virus (HIV) activity and a favorable...
7.
Driscoll J, Siddiqui M, Ford Jr H, Kelley J, Roth J, Mitsuya H, et al.
J Med Chem
. 1996 Apr;
39(8):1619-25.
PMID: 8648601
A series of 6-substituted amino analogs of 9-(2,3-dideoxy-2-fluoro-beta-D-threo-pentofuranosyl) purines (F-ddN) has been synthesized and characterized with the objective of finding compounds which might be superior to existing drugs for the...
8.
AHLUWALIA G, Driscoll J, Ford Jr H, Johns D
J Pharm Sci
. 1996 Apr;
85(4):454-5.
PMID: 8901088
Incorporation of 2'-beta-fluoro-2',3'-dideoxyadenosine (F-ddA), a recently developed anti-HIV agent, into the cellular DNA of human MOLT-4 cells has been compared with the DNA incorporation seen with fialuridine (FIAU; 1-[2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl]-5-iodouracil), a...
9.
Donzanti B, Kelley J, Tomaszewski J, Roth J, Tosca P, Placke M, et al.
Fundam Appl Toxicol
. 1995 Sep;
27(2):167-76.
PMID: 8529811
2'-beta-Fluoro-2',3'-dideoxyadenosine (F-ddA), an acid-stable, purine dideoxynucleoside with in vitro anti-HIV activity, has been selected by the NCI as a clinical trial candidate. A recent report that high, single doses of...
10.
Gao W, Mitsuya H, Driscoll J, Johns D
Biochem Pharmacol
. 1995 Jul;
50(2):274-6.
PMID: 7632173
Ribonucleotide reductase inhibitors such as hydroxyurea (HU) and related compounds, at low, non-toxic doses, enhance the anti-human immunodeficiency virus type 1 (HIV-1) potency of both purine and pyrimidine 2',3'-dideoxynucleosides (ddNs)...