J Radons
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Explore the profile of J Radons including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
261
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Recent Articles
1.
Burkart V, Wang Z, Radons J, Heller B, Herceg Z, Stingl L, et al.
Nat Med
. 1999 Mar;
5(3):314-9.
PMID: 10086388
Human type 1 diabetes results from the selective destruction of insulin-producing pancreatic beta cells during islet inflammation. Cytokines and reactive radicals released during this process contribute to beta-cell death. Here...
2.
Radons J, Burkart V, Kolb H
Diabetes
. 1997 Mar;
46(3):379-85.
PMID: 9032092
Superantigens have been implicated in the pathogenesis of type I diabetes and other immune-mediated diseases. We therefore tested the hypothesis of an abnormal reactivity of the immune system toward bacterial...
3.
Bellmann K, Hui L, Radons J, Burkart V, Kolb H
Diabetes
. 1997 Feb;
46(2):232-6.
PMID: 9000699
In islet cells isolated from normal outbred Wistar rats, the known high vulnerability of islet cells toward oxygen radicals or nitric oxide can be abolished by inducing a stress response,...
4.
Heller B, Burkle A, Radons J, Fengler E, Muller M, Burkart V, et al.
Adv Exp Med Biol
. 1997 Jan;
426:329-34.
PMID: 9544290
No abstract available.
5.
Bellmann K, Wenz A, Radons J, Burkart V, Kleemann R, Kolb H
J Clin Invest
. 1995 Jun;
95(6):2840-5.
PMID: 7769124
When cultures of pancreatic islet cells are exposed to the nitric oxide donor sodium nitroprusside, to enzymatically generated reactive oxygen intermediates or to streptozotocin cell lysis occurs after 4-12 h....
6.
Burkart V, Bellmann K, Radons J, Kolb H
FEBS Lett
. 1995 May;
364(3):259-63.
PMID: 7758579
We show here that preincubation of pancreatic islet cells with alpha-tocopherol significantly improves their resistance to toxic doses of nitric oxide (NO). No protection was afforded by other antioxidants such...
7.
Heller B, Wang Z, Wagner E, Radons J, Burkle A, Fehsel K, et al.
J Biol Chem
. 1995 May;
270(19):11176-80.
PMID: 7744749
Activation of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) is an early response of cells exposed to DNA-damaging compounds such as nitric oxide (NO) or reactive oxygen intermediates (ROI). Excessive poly-(ADP-ribose)...
8.
Radons J, Biewusch U, Grassel S, Geuze H, Hasilik A
Biochem J
. 1994 Sep;
302 ( Pt 2):581-6.
PMID: 8093011
Morphological and biochemical evidence indicates that in several cell types, lysozyme is found in both lysosomes and the medium. Here we report that in calcitriol-treated human promonocytes U937, in which...
9.
Heller B, Burkle A, Radons J, Fengler E, Jalowy A, Muller M, et al.
Biol Chem Hoppe Seyler
. 1994 Sep;
375(9):597-602.
PMID: 7840901
Despite extensive studies on streptozotocin, alloxan and nitric oxide toxicity in pancreatic islets the mechanism of oxygen radical induced islet cell death has not been determined. The present study shows...
10.
Radons J, Heller B, Burkle A, Hartmann B, Rodriguez M, Kroncke K, et al.
Biochem Biophys Res Commun
. 1994 Mar;
199(3):1270-7.
PMID: 8147870
Previous studies have shown that DNA strand breaks are an early consequence of nitric oxide toxicity in pancreatic islet cells. We show here that exposure of islet cells to chemical...