J R Weidner
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Explore the profile of J R Weidner including associated specialties, affiliations and a list of published articles.
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11
Citations
1363
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Recent Articles
1.
Singer I, Scott S, Kawka D, Bayne E, Weidner J, Williams H, et al.
Osteoarthritis Cartilage
. 1998 Apr;
5(6):407-18.
PMID: 9536289
Objective: To analyze the roles of two classes of proteinases, 'aggrecanase', and matrix metalloproteinases (MMPs), in chondrodestruction during murine collagen-induced arthritis (CIA). Methods: Generation of the 'aggrecanase' neo-epitope (NITEGE373), and...
2.
Fenyk-Melody J, Garrison A, Brunnert S, Weidner J, Shen F, Shelton B, et al.
J Immunol
. 1998 Mar;
160(6):2940-6.
PMID: 9510198
Nitric oxide is believed to be a prominent mediator of inflammation based in part on the correlative expression of the inducible nitric oxide synthase (iNOS) gene in various pathologies. The...
3.
Lark M, Bayne E, Flanagan J, Harper C, Hoerrner L, Hutchinson N, et al.
J Clin Invest
. 1997 Jul;
100(1):93-106.
PMID: 9202061
To examine the activity of matrix metalloproteinases (MMPs) and aggrecanase in control and diseased human articular cartilage, metabolic fragments of aggrecan were detected with monospecific antipeptide antibodies. The distribution and...
4.
Calaycay J, Kelly T, MacNaul K, McCauley E, Qi H, Grant S, et al.
J Biol Chem
. 1996 Nov;
271(45):28212-9.
PMID: 8910438
Recombinant human inducible nitric-oxide synthase (rH-iNOS) was expressed in the baculovirus system and purified by a novel immunoaffinity column. rH-iNOS and its native counterpart from cytokine-stimulated primary hepatocytes exhibited similar...
5.
Singer I, Kawka D, Scott S, Weidner J, Mumford R, Riehl T, et al.
Gastroenterology
. 1996 Oct;
111(4):871-85.
PMID: 8831582
Background & Aims: Inducible nitric oxide synthase (iNOS) is generated in several cell types by treatment with lipopolysaccharides or cytokines. Earlier studies suggested that ulcerative colitis is associated with increased...
6.
Nicholson S, Lapa E Silva J, Nathan C, Xie Q, Mumford R, Weidner J, et al.
J Exp Med
. 1996 May;
183(5):2293-302.
PMID: 8642338
The high-output pathway of nitric oxide production helps protect mice from infection by several pathogens, including Mycobacterium tuberculosis. However, based on studies of cells cultured from blood, it is controversial...
7.
Singer I, Kawka D, Bayne E, Donatelli S, Weidner J, Williams H, et al.
J Clin Invest
. 1995 May;
95(5):2178-86.
PMID: 7537757
The destruction of articular cartilage in immune inflammatory arthritic disease involves the proteolytic degradation of its extracellular matrix. The role of activated matrix metalloproteinases (MMPs) in the chondrodestructive process was...
8.
Lark M, Gordy J, Weidner J, Ayala J, Kimura J, Williams H, et al.
J Biol Chem
. 1995 Feb;
270(6):2550-6.
PMID: 7852317
A rat chondrosarcoma cell line and primary bovine chondrocytes have been used to study cell-mediated aggrecan catabolism. Addition of 1 microM retinoic acid to chondrosarcoma cultures resulted in aggrecan proteolysis...
9.
Xie Q, Cho H, Kashiwabara Y, Baum M, Weidner J, Elliston K, et al.
J Biol Chem
. 1994 Nov;
269(45):28500-5.
PMID: 7525576
Cloning of a nitric oxide synthase (NOS) from RAW 264.7 mouse macrophages (Xie, Q.-w., Cho, H. J., Calaycay, J., Mumford, R. A., Swiderek, K. M., Lee, T. D., Ding, A.,...
10.
Thornberry N, Bull H, Calaycay J, Chapman K, Howard A, Kostura M, et al.
Nature
. 1992 Apr;
356(6372):768-74.
PMID: 1574116
Interleukin-1 beta (IL-1 beta)-converting enzyme cleaves the IL-1 beta precursor to mature IL-1 beta, an important mediator of inflammation. The identification of the enzyme as a unique cysteine protease and...