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J R Silvius

Explore the profile of J R Silvius including associated specialties, affiliations and a list of published articles. Areas
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Articles 78
Citations 1332
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Schleiff E, Silvius J, Shore G
J Cell Biol . 1999 Jun; 145(5):973-8. PMID: 10352015
Insertion of newly synthesized proteins into or across the mitochondrial outer membrane is initiated by import receptors at the surface of the organelle. Typically, this interaction directs the precursor protein...
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Rex S, Zuckermann M, LaFleur M, Silvius J
Biophys J . 1998 Nov; 75(6):2900-14. PMID: 9826611
Experimental measurements of the affinity of binding of fluorescent acylated polyethyleneglycol (PEG) conjugates to bilayers containing varying levels of phosphatidylethanolamine-PEGs (PE-PEGs) have been combined with Monte Carlo simulations to investigate...
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Leventis R, Silvius J
Biochemistry . 1998 Jun; 37(20):7640-8. PMID: 9585579
We have examined the association with lipid vesicles of fluorescent lipidated peptides based on the farnesylated, polybasic carboxy-terminal region of mature K-ras4B, which functions physiologically as an autonomous plasma membrane-targeting...
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Schroeder H, Leventis R, Rex S, Schelhaas M, Nagele E, Waldmann H, et al.
Biochemistry . 1997 Oct; 36(42):13102-9. PMID: 9335573
We have used a series of fluorescent lipid-modified peptides, based on the farnesylated C-terminal sequence of mature N-ras [-GCMGLPC(farnesyl)-OCH3], to investigate the membrane-anchoring properties of this region of the protein...
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Leventis R, Juel G, Knudsen J, Silvius J
Biochemistry . 1997 May; 36(18):5546-53. PMID: 9154938
Acyl-CoA binding proteins (ACBPs) from rat and bovine liver were found to inhibit the nonenzymic S-acylation of two representative types of peptides by long-chain acyl-CoAs. As demonstrated previously [Quesnel, S....
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Silvius J, Del Giudice D, LaFleur M
Biochemistry . 1996 Dec; 35(48):15198-208. PMID: 8952467
Fourier-transform infrared-spectroscopic and fluorescence measurements have been combined to examine the effect of cholesterol on the intermixing of short-chain dilauroyl phosphatidylcholine (DLPC) and its bromo-substituted derivative (12BrPC) with longer-chain (C16-...
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Schroeder H, Leventis R, Shahinian S, Walton P, Silvius J
J Cell Biol . 1996 Aug; 134(3):647-60. PMID: 8707845
A variety of cysteine-containing, lipid-modified peptides are found to be S-acylated by cultured mammalian cells. The acylation reaction is highly specific for cysteinyl over serinyl residues and for lipid-modified peptides...
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Steenaart N, Silvius J, Shore G
Biochemistry . 1996 Mar; 35(12):3764-71. PMID: 8619997
Mas70p is targeted and inserted into the mitochondrial outer membrane in the N(in)-C(cyto) orientation, via an NH2-terminal signal-anchor sequence. The signal-anchor is comprised of two domains: an NH2-terminal hydrophilic region...