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J P Le Couedic

Explore the profile of J P Le Couedic including associated specialties, affiliations and a list of published articles. Areas
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Articles 35
Citations 621
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Recent Articles
1.
Hasan S, Cassinat B, Droin N, Le Couedic J, Favale F, Monte-Mor B, et al.
Leukemia . 2013 Oct; 28(2):460-3. PMID: 24150219
No abstract available.
2.
Baccini V, Roy L, Vitrat N, Chagraoui H, Sabri S, Le Couedic J, et al.
Blood . 2001 Nov; 98(12):3274-82. PMID: 11719364
The cyclin-dependent kinase inhibitor p21(Waf-1/Cip-1) is expressed at high level during megakaryocyte differentiation, but its precise function remains unknown. In this study, it is confirmed that p21 was expressed at...
3.
Lagrue-Lak-Hal A, Debili N, Kingbury G, Lecut C, Le Couedic J, Villeval J, et al.
J Biol Chem . 2001 Mar; 276(18):15316-25. PMID: 11278467
In this report, the expression and function of the platelet collagen receptor glycoprotein VI (GPVI) were studied in human megakaryocytes during differentiation and maturation of mobilized blood and cord blood...
4.
Taskin A, Le Couedic J, Abina M, Villeval J, Debili N, Casadevall N, et al.
Stem Cells . 2000 Sep; 16 Suppl 2:155-64. PMID: 11012187
Thrombopoietin (TPO) is the central regulator of megakaryocytopoiesis and thrombocytopoiesis. Preclinical data and human studies have so far shown that the recombinant molecule is safe to administer and associated with...
5.
Jandrot-Perrus M, Busfield S, Lagrue A, Xiong X, Debili N, Chickering T, et al.
Blood . 2000 Aug; 96(5):1798-807. PMID: 10961879
Injuries to the vessel wall and subsequent exposure of collagen from the subendothelial matrix result in thrombus formation. In physiological conditions, the platelet plug limits blood loss. However, in pathologic...
6.
Letestu R, Vitrat N, Masse A, Le Couedic J, Lazar V, Rameau P, et al.
Blood . 2000 Feb; 95(5):1633-41. PMID: 10688818
The thrombocytopenia and absent radii (TAR) syndrome is a rare disease associating bilateral radial agenesis and congenital thrombocytopenia. Here, we investigated in vitro megakaryocyte (MK) differentiation and expression of c-mpl...
7.
Vitrat N, Pique C, Le Couedic J, Norol F, Larsen A, Katz A, et al.
Blood . 1998 Jun; 91(10):3711-23. PMID: 9573008
During megakaryocyte differentiation, the promegakaryoblast (immature megakaryocyte) increases its ploidy to a 2(x) DNA content by a poorly understood process called endomitosis. This leads to the formation of a giant...
8.
Le Couedic J, Mitjavila M, Villeval J, Feger F, Gobert S, Mayeux P, et al.
Blood . 1996 Feb; 87(4):1502-11. PMID: 8608241
Human erythroid malignancies (polycythemia vera [PV] and erythroleukemia) are associated with erythropoietin (Epo)-independent growth and differentiation. Missense or nonsense mutations in the Epo receptor (Epo-R) have been recently described in...
9.
Wechsler J, Bagot M, Henni T, Le Couedic J, Gaulard P, Zafrani E
Arch Pathol Lab Med . 1995 Feb; 119(2):157-62. PMID: 7848063
Background And Design: Patients with cutaneous lymphoid infiltrates that appear reactive histologically and immunophenotypically may develop clinically overt cutaneous lymphoma, suggesting the possibility of misdiagnosis by classical methods. We investigated...
10.
Fermand J, Mitjavila M, Le Couedic J, Tsapis A, Berger R, Modigliani R, et al.
Br J Haematol . 1993 Mar; 83(3):359-64. PMID: 8485042
We studied two patients with a leukaemic T cell lymphoma who presented with a marked increase in blood eosinophilia. To investigate the mechanism of the eosinophilia, supernatants of peripheral blood...