J P Issa
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Explore the profile of J P Issa including associated specialties, affiliations and a list of published articles.
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52
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6134
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Recent Articles
11.
Ahuja N, Issa J
Histol Histopathol
. 2000 Aug;
15(3):835-42.
PMID: 10963127
Alterations in methylation are widespread in cancers. DNA methylation of promoter-associated CpG islands is an alternate mechanism to mutation in silencing gene function, and affects tumor-suppressor genes such as p16...
12.
Toyota M, Shen L, Hamilton S, Sinicrope F, Issa J
Cancer Res
. 2000 Aug;
60(15):4044-8.
PMID: 10945606
Cyclooxygenases (COXs) are key enzymes that convert arachidonic acid to prostaglandins. Overexpression of one of the COX isozymes, COX2, has been shown to play an important role in colorectal cancer...
13.
Issa J
Ann N Y Acad Sci
. 2000 Jul;
910:140-53; discussion 153-5.
PMID: 10911911
Colorectal cancer has provided an excellent model for studying the genetic basis of cancer and is one of the better-understood malignancies in this regard. The orderly progression of the disease,...
14.
Esteller M, Toyota M, Sanchez-Cespedes M, Capella G, Peinado M, Watkins D, et al.
Cancer Res
. 2000 May;
60(9):2368-71.
PMID: 10811111
O6-methylguanine DNA methyltransferase (MGMT) is a DNA repair protein that removes mutagenic and cytotoxic adducts from the O6 position of guanine. O6-methylguanine mispairs with thymine during replication, and if the...
15.
16.
Ueki T, Toyota M, Sohn T, Yeo C, Issa J, Hruban R, et al.
Cancer Res
. 2000 Apr;
60(7):1835-9.
PMID: 10766168
Hypermethylation of CpG islands is a common mechanism by which tumor suppressor genes are inactivated. We studied 45 pancreatic carcinomas and 14 normal pancreata for aberrant DNA methylation of CpG...
17.
Toyota M, Issa J
Electrophoresis
. 2000 Feb;
21(2):329-33.
PMID: 10675010
Cancer development and progression is dictated by a series of alterations in genes such as oncogenes, tumor suppressor genes, DNA repair genes, and others. DNA methylation is an epigenetic modification...
18.
Toyota M, Ahuja N, Issa J
Proc Natl Acad Sci U S A
. 2000 Jan;
97(2):710-5.
PMID: 10639144
Colorectal cancers (CRCs) are characterized by multiple genetic (mutations) and epigenetic (CpG island methylation) alterations, but it is not known whether these evolve independently through stochastic processes. We have recently...
19.
Post W, Goldschmidt-Clermont P, Wilhide C, Heldman A, Sussman M, Ouyang P, et al.
Cardiovasc Res
. 2000 Jan;
43(4):985-91.
PMID: 10615426
Objective: Methylation of the promoter region of the estrogen receptor gene alpha (ER alpha) occurs as a function of age in human colon, and results in inactivation of gene transcription....
20.
Toyota M, Ahuja N, Suzuki H, Itoh F, Imai K, Baylin S, et al.
Cancer Res
. 1999 Dec;
59(21):5438-42.
PMID: 10554013
Aberrant methylation of 5' CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in cancer. In colorectal cancer, a group of tumors is...