J Osuga
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Explore the profile of J Osuga including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
1123
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Recent Articles
11.
Osuga J, Ishibashi S, Oka T, Yagyu H, Tozawa R, Fujimoto A, et al.
Proc Natl Acad Sci U S A
. 2000 Jan;
97(2):787-92.
PMID: 10639158
Hormone-sensitive lipase (HSL) is known to mediate the hydrolysis not only of triacylglycerol stored in adipose tissue but also of cholesterol esters in the adrenals, ovaries, testes, and macrophages. To...
12.
Yahagi N, Shimano H, Hasty A, Amemiya-Kudo M, Okazaki H, Tamura Y, et al.
J Biol Chem
. 1999 Dec;
274(50):35840-4.
PMID: 10585468
Dietary polyunsaturated fatty acids (PUFA) are negative regulators of hepatic lipogenesis that exert their effects primarily at the level of transcription. Sterol regulatory element-binding proteins (SREBPs) are transcription factors responsible...
13.
Shimano H, Yahagi N, Amemiya-Kudo M, Hasty A, Osuga J, Tamura Y, et al.
J Biol Chem
. 1999 Dec;
274(50):35832-9.
PMID: 10585467
To elucidate the physiological role of sterol regulatory element-binding protein-1 (SREBP-1), the hepatic mRNA levels of genes encoding various lipogenic enzymes were estimated in SREBP-1 gene knockout mice after a...
14.
Tozawa R, Ishibashi S, Osuga J, Yagyu H, Oka T, Chen Z, et al.
J Biol Chem
. 1999 Oct;
274(43):30843-8.
PMID: 10521476
Squalene synthase (SS) catalyzes the reductive head-to-head condensation of two molecules of farnesyl diphosphate to form squalene, the first specific intermediate in the cholesterol biosynthetic pathway. We used gene targeting...
15.
Yagyu H, Ishibashi S, Chen Z, Osuga J, Okazaki M, Perrey S, et al.
J Lipid Res
. 1999 Sep;
40(9):1677-85.
PMID: 10484615
Lipoprotein lipase (LPL) is known to play a crucial role in lipoprotein metabolism by hydrolyzing triglycerides; however its role in atherogenesis has yet to be determined. We have previously shown...
16.
Gotoda T, Iizuka Y, Kato N, Osuga J, Bihoreau M, Murakami T, et al.
Nat Genet
. 1999 Jul;
22(3):226-8.
PMID: 10391208
No abstract available.
17.
Ohashi K, Ishibashi S, Yamamoto M, Osuga J, Yazaki Y, Yukawa S, et al.
Arterioscler Thromb Vasc Biol
. 1998 Aug;
18(8):1330-4.
PMID: 9714141
Familial hypobetalipoproteinemia is caused by mutations in the apolipoprotein (apo) B gene. We identified a 57-year-old woman whose plasma total cholesterol and apoB levels were 2.17 mmol/L and 0.03 g/L,...
18.
Osuga J, Yonemoto M, Yamada N, Shimano H, Yagyu H, Ohashi K, et al.
J Clin Invest
. 1998 Jul;
102(2):386-94.
PMID: 9664080
Apo E is a key molecule in the lipoprotein metabolism; thus, genetic manipulation of apo E may prove useful in the treatment of hypercholesterolemia. To test the feasibility of this...
19.
Sun L, Ishibashi S, Osuga J, Harada K, Ohashi K, Gotoda T, et al.
Arterioscler Thromb Vasc Biol
. 1998 Jun;
18(6):941-6.
PMID: 9633935
To characterize the clinical features associated with the Trp64Arg mutation of the beta3-adrenergic receptor (beta3-AR), the effects of this mutation, in particular the homozygous state (Arg/Arg), on obesity, blood pressure,...
20.
Abe H, Yamada N, Kamata K, Kuwaki T, Shimada M, Osuga J, et al.
J Clin Invest
. 1998 May;
101(8):1784-8.
PMID: 9541510
Insulin resistance is often associated with atherosclerotic diseases in subjects with obesity and impaired glucose tolerance. This study examined the effects of insulin resistance on coronary risk factors in IRS-1...