J Osuga
Overview
Explore the profile of J Osuga including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
1123
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Recent Articles
1.
Hasty A, Shimano H, Osuga J, Namatame I, Takahashi A, Yahagi N, et al.
J Biol Chem
. 2001 Jul;
276(40):37402-8.
PMID: 11445560
Leptin-deficient mice (ob/ob) are an excellent murine model for obesity, insulin resistance, and diabetes, all of which are components of a multiple risk factor syndrome that, along with hypercholesterolemia, precipitates...
2.
Gotoda T, Osuga J, Ishibashi S
Nihon Rinsho
. 2001 May;
59 Suppl 2:626-9.
PMID: 11351662
No abstract available.
3.
Yoshikawa T, Shimano H, Amemiya-Kudo M, Yahagi N, Hasty A, Matsuzaka T, et al.
Mol Cell Biol
. 2001 Apr;
21(9):2991-3000.
PMID: 11287605
In an attempt to identify transcription factors which activate sterol-regulatory element-binding protein 1c (SREBP-1c) transcription, we screened an expression cDNA library from adipose tissue of SREBP-1 knockout mice using a...
4.
Tozawa R, Ishibashi S, Osuga J, Yamamoto K, Yagyu H, Ohashi K, et al.
J Biol Chem
. 2001 Mar;
276(16):12624-8.
PMID: 11278827
The asialoglycoprotein receptor is an abundant hetero-oligomeric endocytic receptor that is predominantly expressed on the sinusoidal surface of the hepatocytes. A number of physiological and pathophysiological functions have been ascribed...
5.
Perrey S, Ishibashi S, Yahagi N, Osuga J, Tozawa R, Yagyu H, et al.
Metabolism
. 2001 Feb;
50(1):36-40.
PMID: 11172472
Thiazolidinediones (TZDs) are antidiabetic insulin-sensitizing agents that bind to peroxisome proliferator-activated receptor gamma (PPARgamma) and have potent adipogenic effects on 3T3-L1 preadipocytes. In fully differentiated 3T3-L1 adipocytes, TZDs markedly decreased...
6.
Perrey S, Ishibashi S, Kitamine T, Osuga J, Yagyu H, Chen Z, et al.
Atherosclerosis
. 2001 Jan;
154(1):51-60.
PMID: 11137082
In order to determine the contribution of the low density lipoprotein receptor (LDL-R) to the removal of apoB-containing native lipoproteins by macrophages, we compared the uptake of beta-VLDL in peritoneal...
7.
Ohashi K, Ishibashi S, Osuga J, Tozawa R, Harada K, Yahagi N, et al.
J Lipid Res
. 2000 Aug;
41(8):1199-204.
PMID: 10946006
Abetalipoproteinemia (ABL) is an inherited disease characterized by the virtual absence of apolipoprotein B (apoB)-containing lipoproteins from plasma. Only limited numbers of families have been screened for mutations in the...
8.
Amemiya-Kudo M, Shimano H, Yoshikawa T, Yahagi N, Hasty A, Okazaki H, et al.
J Biol Chem
. 2000 Aug;
275(40):31078-85.
PMID: 10918064
Recent data suggest that sterol regulatory-binding protein (SREBP)-1c plays a key role in the transcriptional regulation of different lipogenic genes mediating lipid synthesis as a key regulator of fuel metabolism....
9.
Hasty A, Shimano H, Yahagi N, Amemiya-Kudo M, Perrey S, Yoshikawa T, et al.
J Biol Chem
. 2000 Jul;
275(40):31069-77.
PMID: 10913129
In vivo studies suggest that sterol regulatory element-binding protein (SREBP)-1 plays a key role in the up-regulation of lipogenic genes in the livers of animals that have consumed excess amounts...
10.
Yagyu H, Kitamine T, Osuga J, Tozawa R, Chen Z, Kaji Y, et al.
J Biol Chem
. 2000 Apr;
275(28):21324-30.
PMID: 10777503
Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes esterification of cellular cholesterol. To investigate the role of ACAT-1 in atherosclerosis, we have generated ACAT-1 null (ACAT-1-/-) mice. ACAT activities were present in the liver...