J Michael Thomson
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Explore the profile of J Michael Thomson including associated specialties, affiliations and a list of published articles.
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23
Citations
7537
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Recent Articles
1.
Laos R, Thomson J, Benner S
Front Microbiol
. 2014 Nov;
5:565.
PMID: 25400626
DNA polymerases have evolved for billions of years to accept natural nucleoside triphosphate substrates with high fidelity and to exclude closely related structures, such as the analogous ribonucleoside triphosphates. However,...
2.
Franklin J, Rankin C, Levy S, Snoddy J, Zhang B, Washington M, et al.
Biochem Biophys Res Commun
. 2013 Sep;
440(1):99-104.
PMID: 24045012
Recent progress has been made in the identification of protein-coding genes and miRNAs that are expressed in and alter the behavior of colonic epithelia. However, the role of long non-coding...
3.
Bhutia Y, Hung S, Krentz M, Patel D, Lovin D, Manoharan R, et al.
PLoS One
. 2013 Jan;
8(1):e53436.
PMID: 23335963
Overexpression of ribonucleotide reductase subunit M2 (RRM2), involved in deoxyribonucleotide synthesis, drives the chemoresistance of pancreatic cancer to nucleoside analogs (e.g., gemcitabine). While silencing RRM2 by synthetic means has shown...
4.
Conkrite K, Sundby M, Mukai S, Thomson J, Mu D, Hammond S, et al.
Genes Dev
. 2011 Aug;
25(16):1734-45.
PMID: 21816922
The miR-17~92 cluster is a potent microRNA-encoding oncogene. Here, we show that miR-17~92 synergizes with loss of Rb family members to promote retinoblastoma. We observed miR-17~92 genomic amplifications in murine...
5.
Zeiner G, Norman K, Thomson J, Hammond S, Boothroyd J
PLoS One
. 2010 Jan;
5(1):e8742.
PMID: 20090903
Background: The apicomplexan parasite Toxoplasma gondii can infect and replicate in virtually any nucleated cell in many species of warm-blooded animals; thus, it has evolved the ability to exploit well-conserved...
6.
Newman M, Thomson J, Hammond S
RNA
. 2008 Jun;
14(8):1539-49.
PMID: 18566191
A hallmark of mammalian embryonic development is the widespread induction of microRNA (miRNA) expression. Surprisingly, the transcription of many of these small, noncoding RNAs is unchanged through development; rather, a...
7.
Yin V, Thomson J, Thummel R, Hyde D, Hammond S, Poss K
Genes Dev
. 2008 Mar;
22(6):728-33.
PMID: 18347091
Appendage regeneration is defined by rapid changes in gene expression that achieve dramatic developmental effects, suggesting involvement of microRNAs (miRNAs). Here, we find dynamic regulation of many miRNAs during zebrafish...
8.
Lu Y, Thomson J, Wong H, Hammond S, Hogan B
Dev Biol
. 2007 Sep;
310(2):442-53.
PMID: 17765889
The miR-17-92 locus encodes a cluster of 7 microRNAs transcribed as a single primary transcript. It can accelerate c-Myc induced B cell lymphoma development and is highly expressed in many...
9.
Thomson J, Parker J, Hammond S
Methods Enzymol
. 2007 Aug;
427:107-22.
PMID: 17720481
MicroRNAs (miRNAs) are small, noncoding RNAs that regulate the expression of target mRNAs. Although thousands of miRNAs have been identified, few have been functionally linked to specific biological pathways. Microarray-based...
10.
Tatsuguchi M, Seok H, Callis T, Thomson J, Chen J, Newman M, et al.
J Mol Cell Cardiol
. 2007 May;
42(6):1137-41.
PMID: 17498736
MicroRNAs (miRNAs) are a recently discovered class of approximately 22-nucleotide regulatory RNAs that post-transcriptionally regulate gene expression. We have recently demonstrated that muscle-specific miRNAs miR-1 and miR-133 play an important...