Eric A Gaucher
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Explore the profile of Eric A Gaucher including associated specialties, affiliations and a list of published articles.
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66
Citations
1956
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Recent Articles
1.
Hoshino Y, Gaucher E
Geobiology
. 2024 Jul;
22(4):e12612.
PMID: 38967402
Steroids are indispensable components of the eukaryotic cellular membrane and the acquisition of steroid biosynthesis was a key factor that enabled the evolution of eukaryotes. The polycyclic carbon structures of...
2.
Hoshino Y, Nettersheim B, Gold D, Hallmann C, Vinnichenko G, van Maldegem L, et al.
Nat Ecol Evol
. 2023 Oct;
7(12):2045-2054.
PMID: 37884688
Fossilized lipids offer a rare glimpse into ancient ecosystems. 2-Methylhopanes in sedimentary rocks were once used to infer the importance of cyanobacteria as primary producers throughout geological history. However, the...
3.
Gutierrez-Rus L, Gamiz-Arco G, Gavira J, Gaucher E, Risso V, Sanchez-Ruiz J
Mol Biol Evol
. 2023 May;
40(6).
PMID: 37235753
Enzymes catalyze the chemical reactions of life. For nearly half of known enzymes, catalysis requires the binding of small molecules known as cofactors. Polypeptide-cofactor complexes likely formed at a primordial...
4.
Tran L, Das S, Zhao L, Finn M, Gaucher E
Biomacromolecules
. 2023 May;
24(5):2003-2008.
PMID: 37126604
The therapeutic value of delivering recombinant uricase to human patients has been appreciated for decades. The development of therapeutic uricases has been hampered by the fact that humans do not...
5.
Gutierrez-Rus L, Gamiz-Arco G, Gavira J, Gaucher E, Risso V, Sanchez-Ruiz J
bioRxiv
. 2023 Mar;
PMID: 36993774
Enzymes catalyze the chemical reactions of life. For nearly half of known enzymes, catalysis requires the binding of small molecules known as cofactors. Polypeptide-cofactor complexes likely formed at a primordial...
6.
Johnson R, Sanchez-Lozada L, Nakagawa T, Rodriguez-Iturbe B, Tolan D, Gaucher E, et al.
Obesity (Silver Spring)
. 2022 Sep;
30(10):1917-1926.
PMID: 36150210
Sixty years ago, the geneticist James Neel proposed that the epidemics of obesity and diabetes today may have evolutionary roots. Specifically, he suggested that our ancestors may have accumulated mutations...
7.
Phylogenetic Articulation of Uric Acid Evolution in Mammals and How It Informs a Therapeutic Uricase
Li Z, Hoshino Y, Tran L, Gaucher E
Mol Biol Evol
. 2021 Oct;
39(1).
PMID: 34718698
The role of uric acid during primate evolution has remained elusive ever since it was discovered over 100 years ago that humans have unusually high levels of the small molecule...
8.
Gamiz-Arco G, Risso V, Gaucher E, Gavira J, Naganathan A, Ibarra-Molero B, et al.
J Mol Biol
. 2021 Oct;
433(24):167321.
PMID: 34687715
Obligate symbionts typically exhibit high evolutionary rates. Consequently, their proteins may differ considerably from their modern and ancestral homologs in terms of both sequence and properties, thus providing excellent models...
9.
de Lima Balico L, Gaucher E
Mol Ther Nucleic Acids
. 2021 Sep;
25:578-584.
PMID: 34589279
The utility of CRISPR-Cas9 to repair or reverse diseased states that arise from recent genetic mutations in the human genome is now widely appreciated. The use of CRISPR to "design"...
10.
Fini M, Lanaspa M, Gaucher E, Boutwell B, Nakagawa T, Wright R, et al.
Cancer Metab
. 2021 Sep;
9(1):32.
PMID: 34526149
Background: Recent studies suggest that fructose, as well as its metabolite, uric acid, have been associated with increased risk for both cancer incidence and growth. Both substances are known to...