J M McKim Jr
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Explore the profile of J M McKim Jr including associated specialties, affiliations and a list of published articles.
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24
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230
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Recent Articles
11.
Choudhuri S, McKim Jr J, Klaassen C
Biochim Biophys Acta
. 1994 Jan;
1225(2):171-9.
PMID: 8280785
Metallothionein (MT) can be induced in mouse liver by a bacterial exotoxin, toxic shock syndrome toxin-1 (TSST-1). Hepatic MT was induced by TSST-1 in a dose-dependent manner from 100 micrograms/kg...
12.
Choudhuri S, McKim Jr J, Klaassen C
Toxicol Appl Pharmacol
. 1993 Mar;
119(1):1-10.
PMID: 8470112
Expression of the metallothionein I (MT-I) gene was studied in liver and brain of control mice and rats, as well as following administration of Cd and lipopolysaccharide (LPS). Time-course studies...
13.
McKim Jr J, McKim Sr J, Naumann S, Hammermeister D, Hoffman A, Klaassen C
Fundam Appl Toxicol
. 1993 Feb;
20(2):190-8.
PMID: 8449391
Microdialysis (MD) is a sampling method that allows continuous in vivo collection of free, unbound chemicals in blood and interstitial fluids. In the present study we describe a surgical method...
14.
Kreppel H, BAUMAN J, Liu J, McKim Jr J, Klaassen C
Fundam Appl Toxicol
. 1993 Feb;
20(2):184-9.
PMID: 8449390
Metallothionein (MT) is a sulfhydryl-rich, metal-binding protein that provides protection against metal toxicity. MT is induced by acute stress, hormones, metals, and various organic compounds. Recently, arsenicals have also been...
15.
BAUMAN J, Madhu C, McKim Jr J, Liu Y, Klaassen C
Toxicol Appl Pharmacol
. 1992 Dec;
117(2):233-41.
PMID: 1471156
Paraquat, a frequently used contact herbicide, produces oxidative stress by undergoing redox cycling and generating reactive oxygen species. Paraquat is also effective at increasing hepatic levels of metallothionein (MT). The...
16.
McKim Jr J, Choudhuri S, Klaassen C
Toxicol Appl Pharmacol
. 1992 Sep;
116(1):117-24.
PMID: 1529444
Metallothionein (MT) has been extensively studied over the past several years because of its probable role in endogenous metal homeostasis and cellular protection. A large body of knowledge now exists...
17.
Choudhuri S, McKim Jr J, Klaassen C
Toxicol Appl Pharmacol
. 1992 Jul;
115(1):64-71.
PMID: 1631896
The degradation of metallothionein (MT) by rat liver was examined. Degradation of MT by liver homogenate was greater than by cytosol. In addition, MT degradation by the homogenate at pH...
18.
BAUMAN J, McKim Jr J, Liu J, Klaassen C
Toxicol Appl Pharmacol
. 1992 Jun;
114(2):188-96.
PMID: 1609410
Metallothionein (MT) is a sulfhydryl-rich protein whose levels are increased by administration of a variety of agents including metals, cytokines, and oxidative stress agents. Recent studies have suggested that MT...
19.
Liu J, McKim Jr J, Liu Y, Klaassen C
In Vitro Cell Dev Biol
. 1992 May;
28A(5):320-6.
PMID: 1597404
Sodium butyrate (NaB), a 4-carbon fatty acid, has been reported to activate the metallothionein (MT) gene in certain carcinoma cell lines. Because the effects of NaB are dependent on the...
20.
McKim Jr J, Liu J, Liu Y, Klaassen C
Toxicol Appl Pharmacol
. 1992 Feb;
112(2):324-30.
PMID: 1539169
Acute exposure to cadmium (Cd) salts results in liver toxicity, while administration of cadmium-metallothionein (CdMT) iv, causes renal damage. When CdMT is administered iv there is a rapid accumulation of...