J M Jaffe
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Explore the profile of J M Jaffe including associated specialties, affiliations and a list of published articles.
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42
Citations
279
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Recent Articles
1.
Jaffe J, Malkowicz S, Walker A, MacBride S, Peschel R, Tomaszewski J, et al.
Cancer Res
. 2000 Apr;
60(6):1626-30.
PMID: 10749132
The enzyme product of SRD5A2, 5alpha-reductase type II, is responsible for converting testosterone to the more metabolically active dihydrotestosterone. Therefore, SRDSA2 may be involved in the development or growth of...
2.
Walker A, Jaffe J, Gunasegaram S, Cummings S, Huang C, Chern H, et al.
Hum Mutat
. 2000 Feb;
12(4):289.
PMID: 10660343
CYP3A4 is involved in the metabolism of numerous biologically active compounds, including testosterone. A genetic variant located in the P450NF (nifedipine) specific element (NFSE) has been identified that disrupts a...
3.
Glutathione S-transferase-mu (GSTM1) and -theta (GSTT1) genotypes in the etiology of prostate cancer
Rebbeck T, Walker A, Jaffe J, White D, Wein A, Malkowicz S
Cancer Epidemiol Biomarkers Prev
. 1999 Apr;
8(4 Pt 1):283-7.
PMID: 10207629
The glutathione S-transferases (GSTs) are involved in the metabolism of numerous potential prostate carcinogens. Common homozygous germ-line deletions exist in the genes that encode GST-mu (GSTM1) and GST-theta (GSTT1) and...
4.
Rebbeck T, Jaffe J, Walker A, Wein A, Malkowicz S
J Natl Cancer Inst
. 1998 Aug;
90(16):1225-9.
PMID: 9719084
Background: Pathways involved in androgen metabolism have been implicated in the etiology of prostate cancer. The goal of this study was to evaluate the effect of CYP3A4, a gene associated...
5.
Tse F, Jaffe J, TROENDLE A
J Clin Pharmacol
. 1992 Jul;
32(7):630-8.
PMID: 1640002
The pharmacokinetics of fluvastatin, a potent inhibitor of hydroxymethylglutaryl-CoA reductase and thus cholesterol synthesis, have been studied in 24 normal male volunteers who received [3H] fluvastatin in three different studies:...
6.
Tse F, Jaffe J, Hassell A, Schran H
J Pharm Pharmacol
. 1989 Sep;
41(9):657-60.
PMID: 2573717
The bioavailability of isradipine has been examined in 7- and 52-week-old rats after oral (12.5 mg kg-1) or intravenous (2.5 mg kg-1) doses as a solution and administration of various...
7.
Tse F, Jaffe J
Biopharm Drug Dispos
. 1988 Mar;
9(2):201-10.
PMID: 3370307
The pharmacokinetics of 3-(decyldimethylsilyl)-N-[2-(4-methylphenyl)-1- phenylethyl] propanamide (DMPP), an inhibitor of acyl-CoA: cholesterol acyltransferase, have been examined in 18 healthy male volunteers who received an oral dose of either 14C-DMPP or...
8.
DAIN J, Jaffe J
Drug Metab Dispos
. 1988 Mar;
16(2):238-42.
PMID: 2898340
Fluperlapine, Sandoz compound NB 106-689, 3-fluoro-6-(4-methyl-1-piperazinyl)-11H-dibenz[b,e]azepine, in a 12-week toxicity study exhibited liver toxicity (moderate to severe hyperlipidosis) when administered to rats in the diet at 40 mg/kg/day and at...
9.
Tse F, Orwig B, Jaffe J, DAIN J
Xenobiotica
. 1987 Oct;
17(10):1259-67.
PMID: 3424872
1. The pharmacokinetics and metabolism of alpha-[(dimethylamino)methyl]-2-(3-ethyl-5-methyl-4-isoxazolyl) -1H-[3-14C]indole-3-methanol, a new hypoglycemic agent, have been studied in 15 healthy male volunteers who received an oral dose of 50 or 200 mg....
10.
Tse F, Jaffe J
Biopharm Drug Dispos
. 1987 Sep;
8(5):437-48.
PMID: 3663880
The pharmacokinetics of 3-(decyldimethylsilyl)-N-[2-(4-methylphenyl)-1-phenylethyl]propanamide (DMPP), an inhibitor of acyl-CoA:cholesterol acyltransferase, have been studied in the dog and the rat using 14C and 3H dual-labelled drug. In both species, gastrointestinal absorption...