J M Jaffe
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Explore the profile of J M Jaffe including associated specialties, affiliations and a list of published articles.
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42
Citations
279
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Recent Articles
11.
Tse F, Orwig B, Jaffe J
Xenobiotica
. 1987 Jun;
17(6):741-9.
PMID: 3630208
1. The disposition of alpha-[(dimethylamino)methyl]-2-(3-ethyl-5-methyl-4 isoxazolyl)-1H-[3-14C]indole-3-methanol, an oral hypoglycaemic drug, has been studied in the rat, dog and monkey. 2. Oral doses of the drug were almost completely absorbed. The...
12.
Handley D, Van Valen R, Tomesch J, Melden M, Jaffe J, Ballard F, et al.
Immunopharmacology
. 1987 Apr;
13(2):125-32.
PMID: 3597060
Intravenous administration of platelet-activating factor (PAF) produces dose-dependent hypotension in several species. We have evaluated a recently developed PAF antagonist, SRI 63-441, for its ability to inhibit the hypotensive effect...
13.
Tse F, Jaffe J, Bhuta S
Fundam Clin Pharmacol
. 1987 Jan;
1(6):479-88.
PMID: 3447935
The pharmacokinetics of tizanidine, a new centrally acting muscle relaxant, have been studied in 18 normal male volunteers who received orally a single 5 mg dose, a single 20 mg...
14.
Tse F, Jaffe J
Eur J Clin Pharmacol
. 1987 Jan;
32(4):361-5.
PMID: 2956112
The pharmacokinetics of PN 200-110 (isradipine), a new calcium channel blocking agent, have been studied in 18 normal male volunteers who received orally a single 5-mg dose, a single 20-mg...
15.
Tse F, Chang T, Jaffe J
Arch Int Pharmacodyn Ther
. 1986 Feb;
279(2):181-94.
PMID: 3963935
The disposition kinetics of antipyrine after a single i.v. dose (75 mg/kg) of [14C]antipyrine were examined in control rats and in rats pretreated with butalbital and phenobarbital. Blood antipyrine data...
16.
Tse F, Chang T, Finkelstein B, Ballard F, Jaffe J
J Pharm Sci
. 1984 Nov;
73(11):1599-602.
PMID: 6520762
The influence of the mode of intravenous dosing and blood sample collection on the pharmacokinetics of 4-[(3-methoxyphenyl)-methyl]-2,2,6,6-tetramethyl-1-oxa-4-aza-2, 6-disilacyclohexane hydrochloride (I) was studied in the rat. Blood samples obtained from the...
17.
Tse F, Jaffe J
Eur J Drug Metab Pharmacokinet
. 1984 Jan;
9(1):65-71.
PMID: 6714270
The disposition of dihydroergotamine methanesulfonate following single subcutaneous doses was studied in man and the rabbit using radiotracer techniques. 3H-Dihydroergotamine was almost immediately and completely absorbed from the injection site;...
18.
Tse F, Jaffe J, DAIN J
J Clin Pharmacol
. 1984 Jan;
24(1):47-57.
PMID: 6707234
The pharmacokinetics of 4-[(3-methoxyphenyl)methyl] -2,2,6,6-tetramethyl-1-oxa-4-aza-2,6-disilacyclohexane (Sandoz compound 58-112), a new chemical entity with a unique myotonolytic effect, was studied in 12 healthy male volunteers who received an oral dose of...
19.
Tse F, Jaffe J, Marty K, SCHWARZ H
J Pharm Pharmacol
. 1984 Jan;
36(1):56-8.
PMID: 6141268
The absorption of 52-522 in the dog was studied by measuring blood concentrations of radioactivity after single oral doses of [14C] 52-522 in a capsule with and without water, also...
20.
Mathur L, Colaizzi J, Jaffe J, Poust R, Shah V
J Pharm Sci
. 1983 Sep;
72(9):1071-2.
PMID: 6631696
A UV method is described for measuring total sulfa drug concentration in dissolution samples. This in vitro measurement was found to correlate well with several in vivo parameters obtained after...