J L Maggs
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Explore the profile of J L Maggs including associated specialties, affiliations and a list of published articles.
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76
Citations
760
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Recent Articles
1.
Maggs J, Smeatham A, Whitehouse S, Charity J, Timperley A, Gie G
Bone Joint J
. 2016 Feb;
98-B(3):307-12.
PMID: 26920954
Aims: We report on the outcome of the Exeter Contemporary flanged cemented all-polyethylene acetabular component with a mean follow-up of 12 years (10 to 13.9). This study reviewed 203 hips...
2.
Tingle M, Mahmud R, Maggs J, Hawley S, Coleman M, Ward S, et al.
Environ Toxicol Pharmacol
. 2011 Jul;
5(2):145-53.
PMID: 21781861
The effect of 2,2'-substitution with fluorine, methyl or trifluoromethyl groups on the toxicity, metabolism and pharmacological activity of dapsone has been investigated in vitro and in vivo. There was marked...
3.
Srivastava A, Maggs J, Antoine D, Williams D, Smith D, Park B
Handb Exp Pharmacol
. 2009 Dec;
(196):165-94.
PMID: 20020263
Drugs are generally converted to biologically inactive forms and eliminated from the body, principally by hepatic metabolism. However, certain drugs undergo biotransformation to metabolites that can interfere with cellular functions...
4.
Mostl E, Maggs J, Schrotter G, Besenfelder U, Palme R
Vet Res Commun
. 2002 Apr;
26(2):127-39.
PMID: 11922482
Twenty-one metabolites were detected in faecal samples collected after infusion of (14C)cortisol into the jugular vein of sheep. Using high-performance liquid chromatography/radiometric analysis plus mass spectrometry. One group of metabolites...
5.
Tettey J, Maggs J, Rapeport W, Pirmohamed M, Park B
Chem Res Toxicol
. 2001 Aug;
14(8):965-74.
PMID: 11511170
Troglitazone (TGZ), a 2,4-thiazolidinedione antidiabetic, causes hepatotoxicity in 1.9% of patients. TGZ is an inducer of, and substrate for, hepatic P450 3A. Microsomal metabolism yields a benzoquinone (TGZQ) and reactive...
6.
ONeill P, Scheinmann F, Stachulski A, Maggs J, Park B
J Med Chem
. 2001 Apr;
44(9):1467-70.
PMID: 11311070
New and greatly improved preparations of the 12alpha,1'beta- (5) and 12beta,1'beta- (6) glucuronides of dihydroartemisinin (DHA, 2) are reported using anomeric hydroxy and imidate glucuronate intermediates. Comparison of the synthetic...
7.
Schulenberg J, Maggs J, Long S, Sher K, Gotham H, Baer J, et al.
Alcohol Clin Exp Res
. 2001 Apr;
25(3):473-7.
PMID: 11290861
This article represents the proceedings of a symposium at the 2000 RSA Meeting in Denver, Colorado. John Schulenberg and Jennifer L. Maggs were Organizers. Stephen W. Long was Chair and...
8.
Elsby R, Maggs J, Ashby J, Park B
J Pharmacol Exp Ther
. 2001 Mar;
297(1):103-13.
PMID: 11259533
Bisphenol A [BPA, 2,2-bis(4-hydroxyphenyl)propane], a xenoestrogen, is a monomer for the synthesis of polycarbonate plastics, epoxy resins, and composites. Metabolism of BPA to the monoglucuronide will determine the extent of...
9.
Elsby R, Maggs J, Ashby J, Paton D, Sumpter J, Park B
J Pharmacol Exp Ther
. 2001 Feb;
296(2):329-37.
PMID: 11160614
Concern that the reproductive health of humans is being affected by exposure to xenoestrogens has led to the development of various in vitro and in vivo screening assays for the...
10.
ONeill P, Miller A, Bishop L, Hindley S, Maggs J, Ward S, et al.
J Med Chem
. 2001 Jan;
44(1):58-68.
PMID: 11141088
The combination of TMSOTf and AgClO(4) promotes the efficient C-10-phenoxylation of dihydroartemisinin (3) in good chemical yield and excellent stereoselectivity. All of the new phenoxy derivatives have potent in vitro...