R C Storr
Overview
Explore the profile of R C Storr including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
40
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0
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Recent Articles
1.
ONeill P, Bishop L, Searle N, Maggs J, Storr R, Ward S, et al.
J Org Chem
. 2000 May;
65(5):1578-82.
PMID: 10814129
No abstract available.
2.
ONeill P, Searle N, Kan K, Storr R, Maggs J, Ward S, et al.
J Med Chem
. 2000 Jan;
42(26):5487-93.
PMID: 10639291
Ten novel, second-generation, fluorinated ether and ester analogues of the potent first-generation analogues artemether (4a) and arteether (4b) have been designed and synthesized. All of the compounds demonstrate high antimalarial...
3.
ONeill P, Willock D, Hawley S, Bray P, Storr R, Ward S, et al.
J Med Chem
. 1997 Feb;
40(4):437-48.
PMID: 9046333
Tebuquine (5) is a 4-aminoquinoline that is significantly more active than amodiaquine (2) and chloroquine (1) both in vitro and in vivo. We have developed a novel more efficient synthetic...
4.
ONeill P, Bishop L, Storr R, Hawley S, Maggs J, Ward S, et al.
J Med Chem
. 1996 Oct;
39(22):4511-4.
PMID: 8893847
Several artemisinin derivatives linked to benzylamino and alkylamino groups were synthesized in order to enhance accumulation within the malaria parasite. The in vitro antimalarial activity was assessed against the chloroquine...
5.
Ruscoe J, Jewell H, Maggs J, ONeill P, Storr R, Ward S, et al.
J Pharmacol Exp Ther
. 1995 Apr;
273(1):393-404.
PMID: 7714794
The adverse reactions associated with the antimalarial amodiaquine (AQ), agranulocytosis and hepatotoxicity, have been attributed to the bioactivation of the drug to a quinone imine metabolite. Therefore the effect of...
6.
ONeill P, Harrison A, Storr R, Hawley S, Ward S, Park B
J Med Chem
. 1994 Apr;
37(9):1362-70.
PMID: 8176713
Amodiaquine (AQ) (2) is a 4-aminoquinoline antimalarial which causes adverse side effects such as agranulocytosis and liver damage. The observed drug toxicity is believed to be related to the formation...
7.
The effect of fluorine substitution on the hepatotoxicity and metabolism of paracetamol in the mouse
Barnard S, Kelly D, Storr R, Park B
Biochem Pharmacol
. 1993 Sep;
46(5):841-9.
PMID: 8373436
The widely used analgesic paracetamol (P) produces fulminant hepatocellular necrosis in humans when taken in overdose. The toxicity is mediated by drug oxidation and depletion of hepatic glutathione. We have,...
8.
Barnard S, Storr R, ONeill P, Park B
J Pharm Pharmacol
. 1993 Aug;
45(8):736-44.
PMID: 7901373
The physicochemical properties and analgesic action of six fluorinated analogues of 4-hydroxyacetanilide (paracetamol) have been investigated. Fluorine substitution adjacent to the hydroxyl group increased lipophilicity and oxidation potential whilst substitution...
9.
Coleman M, Tingle M, Hussain F, Storr R, Park B
J Pharm Pharmacol
. 1991 Nov;
43(11):779-84.
PMID: 1686906
With microsomes prepared from a single human liver, 4,4'-diaminodiphenyl sulphone (DDS), 4-acetyl-4-aminodiphenyl sulphone (MADDS), 4-acetyl-4-aminodiphenyl thioether (MADDT) and 4,4'-diacetyldiphenyl thioether (DADDT) caused significantly greater methaemoglobin formation compared with control. In-vitro...