J Hodgkin
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Explore the profile of J Hodgkin including associated specialties, affiliations and a list of published articles.
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66
Citations
4691
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Recent Articles
1.
Hodgkin J
Genome Biol
. 2001 Dec;
2(11):COMMENT2008.
PMID: 11737938
The number of genes predicted for the Caenorhabditis elegans genome is remarkably high: approximately 20,000, if both protein-coding and RNA-coding genes are counted. This article discusses possible explanations for such...
2.
Epstein A, Gleadle J, McNeill L, Hewitson K, ORourke J, Mole D, et al.
Cell
. 2001 Oct;
107(1):43-54.
PMID: 11595184
HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. Recent studies have defined posttranslational modification by prolyl hydroxylation as a key regulatory event that targets...
3.
ARONOFF R, Baran R, Hodgkin J
Gene
. 2001 May;
268(1-2):153-64.
PMID: 11368911
Premature termination codons trigger a process in eukaryotes known as nonsense mediated decay or mRNA surveillance, resulting in the rapid decay of the aberrant transcript. Studies in C. elegans have...
4.
Hodgkin J, Kuwabara P, Corneliussen B
Curr Biol
. 2001 Jan;
10(24):1615-8.
PMID: 11137017
The Dar (deformed anal region) phenotype, characterized by a distinctive swollen tail, was first detected in a variant strain of Caenorhabditis elegans which appeared spontaneously in 1986 during routine genetic...
5.
Friedman L, Hodgkin J, Kimble J
Dev Biol
. 2000 Dec;
228(2):350-62.
PMID: 11112335
The gon-4 gene is required for gonadogenesis in the nematode Caenorhabditis elegans. Normally, two precursor cells, Z1 and Z4, follow a reproducible pattern of cell divisions to generate the mature...
6.
Gartner A, MILSTEIN S, Ahmed S, Hodgkin J, Hengartner M
Mol Cell
. 2000 Jul;
5(3):435-43.
PMID: 10882129
To maintain genomic stability following DNA damage, multicellular organisms activate checkpoints that induce cell cycle arrest or apoptosis. Here we show that genotoxic stress blocks cell proliferation and induces apoptosis...
7.
8.
Woollard A, Hodgkin J
Genes Dev
. 2000 Mar;
14(5):596-603.
PMID: 10716947
Caenorhabditis elegans mab-9 mutants are defective in hindgut and male tail development because of cell fate transformations in two posterior blast cells, B and F. We have cloned mab-9 and...
9.
MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans
Ahmed S, Hodgkin J
Nature
. 2000 Jan;
403(6766):159-64.
PMID: 10646593
The germ line is an immortal cell lineage that is passed indefinitely from one generation to the next. To identify the genes that are required for germline immortality, we isolated...
10.
Blelloch R, Gao D, Li Y, Hodgkin J, Kimble J
Dev Biol
. 1999 Dec;
216(1):382-93.
PMID: 10588887
In wild-type Caenorhabditis elegans, the gonad is a complex epithelial tube that consists of long arms composed predominantly of germline tissue as well as somatic structures specialized for particular reproductive...