H R Horvitz
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Explore the profile of H R Horvitz including associated specialties, affiliations and a list of published articles.
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169
Citations
20446
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Recent Articles
1.
Horvitz H, Sternberg P
J Nematol
. 2009 Mar;
14(2):240-8.
PMID: 19295705
The complete postembryonic ceil lineages of the free-living nentatodes Caenorhabditis elegans and Panagrellus redivivus are known. Postembryonic cell divisions lead to substantial increases in the number of cells and, in...
2.
Kwiatkowski Jr T, Bosco D, Leclerc A, Tamrazian E, Vanderburg C, Russ C, et al.
Science
. 2009 Mar;
323(5918):1205-8.
PMID: 19251627
Amyotrophic lateral sclerosis (ALS) is a fatal degenerative motor neuron disorder. Ten percent of cases are inherited; most involve unidentified genes. We report here 13 mutations in the fused in...
3.
Morita M, Al-Chalabi A, Andersen P, Hosler B, Sapp P, Englund E, et al.
Neurology
. 2006 Jan;
66(6):839-44.
PMID: 16421333
Objective: To perform genetic linkage analysis in a family affected with ALS and frontotemporal dementia (FTD). Methods: The authors performed a genome-wide linkage analysis of a four-generation, 50-member Scandinavian family...
4.
Ceol C, Horvitz H
Dev Cell
. 2004 Apr;
6(4):563-76.
PMID: 15068795
The class A and class B synMuv genes are functionally redundant negative regulators of a Ras signaling pathway that induces C. elegans vulval development. A number of class B synMuv...
5.
STARR D, HERMANN G, Malone C, Fixsen W, Priess J, Horvitz H, et al.
Development
. 2001 Dec;
128(24):5039-50.
PMID: 11748140
Nuclear migration plays an essential role in the growth and development of a wide variety of eukaryotes. Mutations in unc-84, which encodes a conserved component of the nuclear envelope, have...
6.
Lundquist E, Reddien P, Hartwieg E, Horvitz H, Bargmann C
Development
. 2001 Nov;
128(22):4475-88.
PMID: 11714673
The Caenorhabditis elegans genome contains three rac-like genes, ced-10, mig-2, and rac-2. We report that ced-10, mig-2 and rac-2 act redundantly in axon pathfinding: inactivating one gene had little effect,...
7.
Zhou Z, Caron E, Hartwieg E, Hall A, Horvitz H
Dev Cell
. 2001 Nov;
1(4):477-89.
PMID: 11703939
The C. elegans gene ced-12 functions in the engulfment of apoptotic cells and in cell migration, acting in a signaling pathway with ced-2 Crkll, ced-5 DOCK180, and ced-10 Rac GTPase...
8.
Ranganathan R, Sawin E, Trent C, Horvitz H
J Neurosci
. 2001 Aug;
21(16):5871-84.
PMID: 11487610
We isolated two mutants defective in the uptake of exogenous serotonin (5-HT) into the neurosecretory motor neurons of Caenorhabditis elegans. These mutants were hypersensitive to exogenous 5-HT and hyper-responsive in...
9.
Ceol C, Horvitz H
Mol Cell
. 2001 Jul;
7(3):461-73.
PMID: 11463372
The synthetic multivulva (synMuv) genes define two functionally redundant pathways that antagonize RTK/Ras signaling during Caenorhabditis elegans vulval induction. The synMuv gene lin-35 encodes a protein similar to the mammalian...
10.
Reddien P, Cameron S, Horvitz H
Nature
. 2001 Jul;
412(6843):198-202.
PMID: 11449278
In the nematode Caenorhabditis elegans programmed cell death requires the killer genes egl-1, ced-4 and ced-3 (refs 1 and 2), and the engulfment of dying cells requires the genes ced-1,...