J Graham McGeown
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Explore the profile of J Graham McGeown including associated specialties, affiliations and a list of published articles.
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40
Citations
805
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Recent Articles
1.
OHare M, Esquiva G, McGahon M, Hombrebueno J, Augustine J, Canning P, et al.
JCI Insight
. 2022 Sep;
7(18).
PMID: 36134661
Loss of retinal blood flow autoregulation is an early feature of diabetes that precedes the development of clinically recognizable diabetic retinopathy (DR). Retinal blood flow autoregulation is mediated by the...
2.
Barabas P, Augustine J, Fernandez J, McGeown J, McGahon M, Curtis T
Curr Top Membr
. 2020 May;
85:187-226.
PMID: 32402639
Retinal pressure autoregulation is an important mechanism that protects the retina by stabilizing retinal blood flow during changes in arterial or intraocular pressure. Similar to other vascular beds, retinal pressure...
3.
OLeary C, McGahon M, Ashraf S, McNaughten J, Friedel T, Cincola P, et al.
Invest Ophthalmol Vis Sci
. 2019 Aug;
60(10):3297-3309.
PMID: 31369032
Purpose: We investigate the contribution of TRPV1 and TRPV4 channels to retinal angiogenesis. Methods: Primary retinal microvascular endothelial cells (RMECs) were used for RT-PCR, Western blotting, immunolabeling, Ca2+ signaling, and...
4.
Ashraf S, Bell S, OLeary C, Canning P, Micu I, Fernandez J, et al.
JCI Insight
. 2019 Feb;
4(6).
PMID: 30721154
While anti-VEGF drugs are commonly used to inhibit pathological retinal and choroidal neovascularization, not all patients respond in an optimal manner. Mechanisms underpinning resistance to anti‑VEGF therapy include the upregulation...
5.
McDowell R, Barabas P, Augustine J, Chevallier O, McCarron P, Chen M, et al.
Diabetologia
. 2018 Aug;
61(12):2654-2667.
PMID: 30112688
Aims/hypothesis: Recent studies suggest that abnormal function in Müller glial cells plays an important role in the pathogenesis of diabetic retinopathy. This is associated with the selective accumulation of the...
6.
Curtis T, McLaughlin D, OHare M, Kur J, Barabas P, Revolta G, et al.
J Vis Exp
. 2018 Jul;
(137).
PMID: 30059036
The retina is a highly metabolically active tissue that requires a substantial blood supply. The retinal circulation supports the inner retina, while the choroidal vessels supply the photoreceptors. Alterations in...
7.
Clarke R, Monaghan K, About I, Griffin C, Sergeant G, El Karim I, et al.
Eur Respir J
. 2017 Sep;
50(3).
PMID: 28931666
The cough reflex becomes hyperresponsive in acute and chronic respiratory diseases, but understanding the underlying mechanism is hampered by difficulty accessing human tissue containing both nerve endings and neuronal cell...
8.
McGahon M, Fernandez J, Dash D, McKee J, Simpson D, Zholos A, et al.
Invest Ophthalmol Vis Sci
. 2016 Oct;
57(13):5637-5647.
PMID: 27784066
Purpose: Activation of the transient receptor potential channels, TRPC6, TRPM4, and TRPP1 (PKD2), has been shown to contribute to the myogenic constriction of cerebral arteries. In the present study we...
9.
McDowell R, McGahon M, Augustine J, Chen M, McGeown J, Curtis T
Invest Ophthalmol Vis Sci
. 2016 Sep;
57(11):4762-71.
PMID: 27618414
Purpose: We studied whether the accumulation of advanced lipoxidation end-products (ALEs) in the diabetic retina is linked to the impairment of lipid aldehyde detoxification mechanisms. Methods: Retinas were collected from...
10.
White J, Cibelli M, Urban L, Nilius B, McGeown J, Nagy I
Physiol Rev
. 2016 Jun;
96(3):911-73.
PMID: 27252279
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol 2: 695-702, 2000) and...