J Graham McGeown
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Explore the profile of J Graham McGeown including associated specialties, affiliations and a list of published articles.
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40
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Recent Articles
11.
Fernandez J, McGahon M, McGeown J, Curtis T
Invest Ophthalmol Vis Sci
. 2015 Aug;
56(9):5125-32.
PMID: 26241400
Purpose: Although L-type Ca2+ channels are known to play a key role in the myogenic reactivity of retinal arterial vessels, the involvement of other types of voltage-gated Ca2+ channels in...
12.
Monaghan K, McNaughten J, McGahon M, Kelly C, Kyle D, Yong P, et al.
PLoS One
. 2015 Jun;
10(6):e0128359.
PMID: 26047504
Retinal endothelial cell dysfunction is believed to play a key role in the etiology and pathogenesis of diabetic retinopathy. Numerous studies have shown that TRPV4 channels are critically involved in...
13.
Kur J, McGahon M, Fernandez J, Scholfield C, McGeown J, Curtis T
Invest Ophthalmol Vis Sci
. 2014 Apr;
55(5):2893-902.
PMID: 24699382
Purpose: To investigate the mechanisms responsible for the dilatation of rat retinal arterioles in response to arachidonic acid (AA). Methods: Changes in the diameter of isolated, pressurized rat retinal arterioles...
14.
Fernandez J, Bankhead P, Zhou H, McGeown J, Curtis T
PLoS One
. 2014 Mar;
9(3):e91791.
PMID: 24626349
Pressure myography studies have played a crucial role in our understanding of vascular physiology and pathophysiology. Such studies depend upon the reliable measurement of changes in the diameter of isolated...
15.
Needham M, McGahon M, Bankhead P, Gardiner T, Scholfield C, Curtis T, et al.
Invest Ophthalmol Vis Sci
. 2014 Mar;
55(4):2157-65.
PMID: 24609622
Purpose: This study tested the role of K(+) and Cl(-) channels in the regulation of retinal blood flow. Methods: Studies were carried out in adult Male Hooded Lister rats. Selectivity...
16.
Cahoon J, Olson P, Nielson S, Miya T, Bankhead P, McGeown J, et al.
Exp Eye Res
. 2013 Dec;
120:15-9.
PMID: 24333760
Simultaneous non-invasive visualization of blood vessels and nerves in patients can be obtained in the eye. The retinal vasculature is a target of many retinopathies. Inflammation, readily manifest by leukocyte...
17.
Hinds K, Monaghan K, Frolund B, McGeown J, Curtis T
Invest Ophthalmol Vis Sci
. 2013 Sep;
54(10):6798-805.
PMID: 24045989
Purpose: To investigate the role of γ-aminobutryic acid (GABA) in the regulation of arteriolar diameter in the rat retina. Methods: The actions of GABA on arteriolar diameter were examined using...
18.
McDowell R, McGeown J, Stitt A, Curtis T
Future Med Chem
. 2013 Jan;
5(2):189-211.
PMID: 23360143
Lipoxidation reactions and the subsequent accumulation of advanced lipoxidation end products (ALEs) have been implicated in the pathogenesis of many of the leading causes of visual impairment. Here, we begin...
19.
Gray S, McGeown J, McMurray G, McCloskey K
PLoS One
. 2013 Jan;
8(1):e53423.
PMID: 23326426
Several populations of interstitial cells of Cajal (ICC) exist in the bladder, associated with intramural nerves. Although ICC respond to exogenous agonists, there is currently no evidence of their functional...
20.
Bankhead P, Scholfield C, McGeown J, Curtis T
PLoS One
. 2012 Mar;
7(3):e32435.
PMID: 22427837
The relationship between changes in retinal vessel morphology and the onset and progression of diseases such as diabetes, hypertension and retinopathy of prematurity (ROP) has been the subject of several...