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J Egebjerg

Explore the profile of J Egebjerg including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 35
Citations 796
Followers 0
Related Specialties
Molecular Biology
Pharmacology
Microbiology
Top 10 Co-Authors
R A Garrett
P Krogsgaard-Larsen
T B Stensbol
U Madsen
T N Johansen
J Christiansen
J S Kastrup
K Frydenvang
S F Traynelis
T Liljefors
Published In
J Mol Biol
Eur J Pharmacol
Br J Pharmacol
Neuron
Biochimie
Affiliations
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Recent Articles
1.
A novel dualistic profile of an allosteric AMPA receptor modulator identified through studies on recombinant receptors, mouse hippocampal synapses and crystal structures
Christiansen G, Harbak B, Hede S, Gouliaev A, Olsen L, Frydenvang K, et al.
Neuroscience . 2015 Oct; 310:709-22. PMID: 26450748
Positive allosteric modulators (PAMs) of 2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptors receive increasing interest as therapeutic drugs and have long served as important experimental tools in the study of the molecular mechanisms...
2.
Distribution of serotonin receptor 5-HT6 mRNA in rat neuronal subpopulations: A double in situ hybridization study
Helboe L, Egebjerg J, de Jong I
Neuroscience . 2015 Oct; 310:442-54. PMID: 26424380
The 5-HT6 receptor (5-HT6R) is almost exclusively expressed in the brain and has emerged as a promising target for cognitive disorders, including Alzheimer's disease. In the present study, we have...
3.
Selectivity of (3)H-MADAM binding to 5-hydroxytryptamine transporters in vitro and in vivo in mice; correlation with behavioural effects
Larsen A, Brennum L, Egebjerg J, Sanchez C, Halldin C, Andersen P
Br J Pharmacol . 2004 Mar; 141(6):1015-23. PMID: 14993096
1. Binding of the novel radioligand (3)H-2-(2-dimethylaminomethyl-phenylsulphanyl)-5-methyl-phenylamine ((3)H-MADAM) to the serotonin transporter (SERT) was used to characterise a range of selective serotonin re-uptake inhibitors (SSRIs) in vitro and in vivo....
4.
GluR2 ligand-binding core complexes: importance of the isoxazolol moiety and 5-substituent for the binding mode of AMPA-type agonists
Kasper C, Liljefors T, Gouaux E, Egebjerg J, Kastrup J
FEBS Lett . 2002 Nov; 531(2):173-8. PMID: 12417307
X-ray structures of the GluR2 ligand-binding core in complex with (S)-Des-Me-AMPA and in the presence and absence of zinc ions have been determined. (S)-Des-Me-AMPA, which is devoid of a substituent...
5.
Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core
Hogner A, Kastrup J, Jin R, Liljefors T, Mayer M, Egebjerg J, et al.
J Mol Biol . 2002 Sep; 322(1):93-109. PMID: 12215417
Glutamate is the principal excitatory neurotransmitter within the mammalian CNS, playing an important role in many different functions in the brain such as learning and memory. In this study, a...
6.
CRM1 mediates the export of ADAR1 through a nuclear export signal within the Z-DNA binding domain
POULSEN H, Nilsson J, Damgaard C, Egebjerg J, Kjems J
Mol Cell Biol . 2001 Oct; 21(22):7862-71. PMID: 11604520
RNA editing of specific residues by adenosine deamination is a nuclear process catalyzed by adenosine deaminases acting on RNA (ADAR). Different promoters in the ADAR1 gene give rise to two...
7.
Characteristics of AMPA receptor-mediated responses of cultured cortical and spinal cord neurones and their correlation to the expression of glutamate receptor subunits, GluR1-4
Dai W, Egebjerg J, Lambert J
Br J Pharmacol . 2001 Apr; 132(8):1859-75. PMID: 11309259
Electrophysiological recordings have been used to characterize responses mediated by AMPA receptors expressed by cultured rat cortical and spinal cord neurones. The EC(50) values for AMPA were 17 and 11...
8.
Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist
Stensbol T, Jensen H, Nielsen B, Johansen T, Egebjerg J, Frydenvang K, et al.
Eur J Pharmacol . 2001 Feb; 411(3):245-53. PMID: 11164381
(RS)-2-Amino-3-(5-tert-butyl-3-hydroxy-4-isothiazolyl)propionic acid (thio-ATPA), a 3-isothiazolol analogue of (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid (ATPA), has previously been shown to be a relatively weak AMPA receptor agonist at native (S)-glutamic acid ((S)-Glu) receptors (EC(50)=14 microM),...
9.
Larger intercellular variation in (Q/R) editing of GluR6 than GluR5 revealed by single cell RT-PCR
Christensen K, Dai W, Lambert J, Egebjerg J
Neuroreport . 2000 Nov; 11(16):3577-82. PMID: 11095522
RNA editing of the pre-mRNA encoding the kainate receptor subtypes determines the Ca2+ permeability and the rectifying properties of the receptors in which these are assembled. GluR6 pre-mRNA contains three...
10.
Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H- tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist
Vogensen S, Jensen H, Stensbol T, Frydenvang K, Bang-Andersen B, Johansen T, et al.
Chirality . 2000 Oct; 12(10):705-13. PMID: 11054828
We have previously shown that (RS)-2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol -4-yl] propionic acid (2-Me-Tet-AMPA) is a selective agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, markedly more potent than AMPA itself, whereas the isomeric compound 1-Me-Tet-AMPA...