J E Towne
Overview
Explore the profile of J E Towne including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
427
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0
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Recent Articles
1.
Kock K, Pan W, Gow J, Horner M, Gibbs J, Colbert A, et al.
Br J Pharmacol
. 2014 Sep;
172(1):159-72.
PMID: 25205227
Background And Purpose: AMG 139 is a human anti-IL-23 antibody currently in a phase II trial for treating Crohn's disease. To support its clinical development in humans, in vitro assays...
2.
Towne J, Sims J
Curr Opin Pharmacol
. 2012 Mar;
12(4):486-90.
PMID: 22398321
Psoriasis is a common but severe skin disease with significant health consequences, both physical and psychological. Evidence has emerged during the past several years pointing to a key role for...
3.
Symons A, Budelsky A, Towne J
Mucosal Immunol
. 2011 Nov;
5(1):4-6.
PMID: 22071661
Th17 cells are abundant in multiple chronic inflammatory and autoimmune diseases. Clinical trials with antibodies to interleukin (IL)-17A, one of the Th17-cell signature cytokines, have recently reported therapeutic benefit in...
4.
Schmitz H, Towne J
Surg Gynecol Obstet
. 2010 Mar;
84(5):962-6.
PMID: 20295758
No abstract available.
5.
Schmitz H, Towne J
Am J Obstet Gynecol
. 2010 Mar;
53(2):199-206.
PMID: 20286630
No abstract available.
6.
Krane C, Fortner C, Hand A, McGraw D, Lorenz J, Wert S, et al.
Proc Natl Acad Sci U S A
. 2001 Nov;
98(24):14114-9.
PMID: 11707570
Although aquaporin 5 (AQP5) is the major water channel expressed in alveolar type I cells in the lung, its actual role in the lung is a matter of considerable speculation....
7.
Krane C, Melvin J, Nguyen H, Richardson L, Towne J, Doetschman T, et al.
J Biol Chem
. 2001 Apr;
276(26):23413-20.
PMID: 11290736
Aquaporins (AQPs) are channel proteins that regulate the movement of water through the plasma membrane of secretory and absorptive cells in response to osmotic gradients. In the salivary gland, AQP5...
8.
Towne J, Krane C, Bachurski C, Menon A
J Biol Chem
. 2001 Mar;
276(22):18657-64.
PMID: 11279049
Aquaporin 5 (AQP5), the major water channel expressed in alveolar, tracheal, and upper bronchial epithelium, is significantly down-regulated during pulmonary inflammation and edema. The mechanisms that underlie this decrease in...
9.
Towne J, Harrod K, Krane C, Menon A
Am J Respir Cell Mol Biol
. 1999 Dec;
22(1):34-44.
PMID: 10615063
Intratracheal infection of mice with adenovirus is associated with subsequent pulmonary inflammation and edema. Water movement through the air space-capillary barrier in the distal lung is facilitated by aquaporins (AQPs)....
10.
Krane C, Towne J, Menon A
Mamm Genome
. 1999 May;
10(5):498-505.
PMID: 10337625
Aquaporin 5 (Aqp5), a member of the aquaporin family of membrane water channels, is thought to modulate the osmolality of fluids in the eye, lung, and salivary gland. Here, we...