J P Gibbs
Overview
Explore the profile of J P Gibbs including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
32
Citations
419
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0
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Recent Articles
1.
Chen P, Olsson Gisleskog P, Perez-Ruixo J, Xiao J, Wilkins J, Narayanan A, et al.
CPT Pharmacometrics Syst Pharmacol
. 2016 Sep;
5(9):484-94.
PMID: 27639083
Etelcalcetide is a novel calcimimetic in development for the treatment of secondary hyperparathyroidism (SHPT). A population pharmacokinetic/pharmacodynamic (PK/PD) model was developed relating etelcalcetide exposures to markers of efficacy (parathyroid hormone...
2.
Mould D, Walz A, Lave T, Gibbs J, Frame B
CPT Pharmacometrics Syst Pharmacol
. 2015 Jul;
4(1):e00016.
PMID: 26225225
Anticancer agents often have a narrow therapeutic index (TI), requiring precise dosing to ensure sufficient exposure for clinical activity while minimizing toxicity. These agents frequently have complex pharmacology, and combination...
3.
Kock K, Pan W, Gow J, Horner M, Gibbs J, Colbert A, et al.
Br J Pharmacol
. 2014 Sep;
172(1):159-72.
PMID: 25205227
Background And Purpose: AMG 139 is a human anti-IL-23 antibody currently in a phase II trial for treating Crohn's disease. To support its clinical development in humans, in vitro assays...
4.
Dodds M, Salinger D, Mandema J, Gibbs J, Gibbs M
CPT Pharmacometrics Syst Pharmacol
. 2013 Jul;
2:e58.
PMID: 23884206
Clinical trial simulation (CTS) and model-based meta-analysis (MBMA) can increase our understanding of small, first-in-patient (FIP) trial design performance to inform Phase 2 decision making. In this work, we compared...
5.
6.
Sanchez C, Crump K, Krieger R, Khandaker N, Gibbs J
Environ Sci Technol
. 2006 Feb;
39(24):9391-7.
PMID: 16475313
In previous studies trace levels of perchlorate were found in lettuce (Lactuca sativa L.) irrigated with Colorado River water, which is contaminated with low levels of perchlorate from aerospace and...
7.
Rosenbaum H, Weinrich M, Stoleson S, Gibbs J, Baker C, DeSalle R
J Hered
. 2003 Mar;
93(6):389-99.
PMID: 12642638
To examine whether demographic and life-history traits are correlated with genetic structure, we contrasted mtDNA lineages of individual humpback whales (Megaptera novaeangliae) with sighting and reproductive histories of female humpback...
8.
McCune J, Gooley T, Gibbs J, Sanders J, Petersdorf E, Appelbaum F, et al.
Bone Marrow Transplant
. 2002 Aug;
30(3):167-73.
PMID: 12189535
We retrospectively analyzed the relationship between busulfan average steady-state plasma concentration (C(SS)) and graft rejection in 53 children receiving busulfan/cyclophosphamide (BU/CY) preparative regimens prior to hematopoietic stem cell transplantation (HSCT)....
9.
McCune J, Gibbs J, Slattery J
Clin Pharmacokinet
. 2000 Sep;
39(2):155-65.
PMID: 10976660
High dosage busulfan (1 mg/kg orally every 6 hours x 16 doses) is frequently used in preparative regimens for haemopoietic stem cell transplantation (HSCT). Busulfan is well absorbed after oral...
10.
Crump C, Michaud P, Tellez R, Reyes C, Gonzalez G, MONTGOMERY E, et al.
J Occup Environ Med
. 2000 Jun;
42(6):603-12.
PMID: 10874653
Perchlorate is known to suppress thyroid function by inhibiting uptake of iodide by the human thyroid at doses of 200 mg/day or greater. A study was conducted to investigate the...