J Domagala
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Explore the profile of J Domagala including associated specialties, affiliations and a list of published articles.
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44
Citations
509
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Recent Articles
1.
Dziewulska K, Rzemieniecki A, Czerniawski R, Domagala J
Theriogenology
. 2011 Apr;
76(2):300-11.
PMID: 21496895
The cryopreservation of salmonid sperm is a complex process involving the interplay of many factors. Although cryopreservation protocols can be evaluated through a range of responses at various stages in...
2.
Lu T, Zhao X, Li X, Drlica-Wagner A, Wang J, Domagala J, et al.
Antimicrob Agents Chemother
. 2001 Sep;
45(10):2703-9.
PMID: 11557458
The increasing prevalence of antibiotic resistance among bacterial pathogens prompted a microbiological study of fluoroquinolone structure-activity relationships with resistant mutants. Bacteriostatic and bactericidal activities for 12 fluoroquinolones were examined with...
3.
Hagen S, Domagala J, Gajda C, Lovdahl M, Tait B, Wise E, et al.
J Med Chem
. 2001 Jun;
44(14):2319-32.
PMID: 11428926
Due largely to the emergence of multi-drug-resistant HIV strains, the development of new HIV protease inhibitors remains a high priority for the pharmaceutical industry. Toward this end, we previously identified...
4.
Sharmeen L, McQuade T, Heldsinger A, Gogliotti R, Domagala J, Gracheck S
Antiviral Res
. 2001 Mar;
49(2):101-14.
PMID: 11248362
A new class of substituted 2'-benzisothiazolone represented by PD 161374 was discovered with antiviral activity against retroviruses similar to previously described nucleocapsid inhibitor PD 159206 (DIBA-4). In T cell culture,...
5.
Sindelar G, Zhao X, Liew A, Dong Y, Lu T, Zhou J, et al.
Antimicrob Agents Chemother
. 2000 Nov;
44(12):3337-43.
PMID: 11083637
Mutant prevention concentration (MPC) has been proposed as a new measure of antibiotic potency by which the ability to restrict selection of resistant mutants is evaluated. To determine whether MPC...
6.
Zhou J, Dong Y, Zhao X, Lee S, Amin A, Ramaswamy S, et al.
J Infect Dis
. 2000 Jul;
182(2):517-25.
PMID: 10915083
To obtain a general framework for understanding selection of antibiotic-resistant mutants, allelic diversity was examined with about 600 fluoroquinolone-resistant mutants of mycobacteria. Selection at low fluoroquinolone concentration produced many low-level...
7.
Ellsworth E, Domagala J, Prasad J, Hagen S, Ferguson D, Holler T, et al.
Bioorg Med Chem Lett
. 1999 Aug;
9(14):2019-24.
PMID: 10450973
5,6-Dihydro-2H-pyran-2-ones are potent inhibitors of HIV-1 protease, which bind to the S1, S2, S1', and S2' pockets and have a unique binding mode with the catalytic aspartyl groups and the...
8.
Dong Y, Zhao X, Domagala J, Drlica K
Antimicrob Agents Chemother
. 1999 Jul;
43(7):1756-8.
PMID: 10390236
When Mycobacterium bovis BCG and Staphylococcus aureus were plated on agar containing increasing concentrations of fluoroquinolone, colony numbers exhibited a sharp drop, followed by a plateau and a second sharp...
9.
Zhao B, Pine R, Domagala J, Drlica K
Antimicrob Agents Chemother
. 1999 Feb;
43(3):661-6.
PMID: 10049284
When the lethal action of a C-8 methoxyl fluoroquinolone against clinical isolates of Mycobacterium tuberculosis in liquid medium was measured, the compound was found to be three to four times...
10.
Dong Y, Xu C, Zhao X, Domagala J, Drlica K
Antimicrob Agents Chemother
. 1998 Oct;
42(11):2978-84.
PMID: 9797236
Fluoroquinolones trap gyrase on DNA as bacteriostatic complexes from which lethal DNA breaks are released. Substituents at the C-8 position increase activities of N-1-cyclopropyl fluoroquinolones against several bacterial species. In...