J David Lambeth
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Explore the profile of J David Lambeth including associated specialties, affiliations and a list of published articles.
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60
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7009
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Recent Articles
1.
De La Cruz J, Ganesh T, Diebold B, Cao W, Hofstetter A, Singh N, et al.
PLoS One
. 2021 Jul;
16(7):e0254632.
PMID: 34280220
Superoxide radicals and other reactive oxygen species (ROS) are implicated in influenza A virus-induced inflammation. In this in vitro study, we evaluated the effects of TG6-44, a novel quinazolin-derived myeloperoxidase-specific...
2.
Diebold B, Wilder S, De Deken X, Meitzler J, Doroshow J, McCoy J, et al.
Methods Mol Biol
. 2019 Jun;
1982:191-229.
PMID: 31172474
The identification of NADPH oxidase (NOX) isoforms in tissues is essential for interpreting experiments and for next step decisions regarding cell lines, animal models, and targeted drug design. Two basic...
3.
Hofstetter A, De La Cruz J, Cao W, Patel J, Belser J, McCoy J, et al.
PLoS One
. 2016 Feb;
11(2):e0149864.
PMID: 26910342
The role of the reactive oxygen species-producing NADPH oxidase family of enzymes in the pathology of influenza A virus infection remains enigmatic. Previous reports implicated NADPH oxidase 2 in influenza...
4.
Zielonka J, Zielonka M, VerPlank L, Cheng G, Hardy M, Ouari O, et al.
J Biol Chem
. 2016 Feb;
291(13):7029-44.
PMID: 26839313
Using high throughput screening-compatible assays for superoxide and hydrogen peroxide, we identified potential inhibitors of the NADPH oxidase (Nox2) isoform from a small library of bioactive compounds. By using multiple...
5.
Li Y, Ganesh T, Diebold B, Zhu Y, McCoy J, Smith S, et al.
ACS Med Chem Lett
. 2015 Oct;
6(10):1047-52.
PMID: 26487910
Myeloperoxidase (MPO) is a key antimicrobial enzyme, playing a normal role in host defense, but also contributing to inflammatory conditions including neuroinflammatory diseases such as Parkinson's and Alzheimer's. We synthesized...
6.
Nisimoto Y, Diebold B, Cosentino-Gomes D, Constentino-Gomes D, Lambeth J
Biochemistry
. 2014 Jul;
53(31):5111-20.
PMID: 25062272
Nox4 is an oddity among members of the Nox family of NADPH oxidases [seven isoenzymes that generate reactive oxygen species (ROS) from molecular oxygen] in that it is constitutively active....
7.
Zielonka J, Cheng G, Zielonka M, Ganesh T, Sun A, Joseph J, et al.
J Biol Chem
. 2014 Apr;
289(23):16176-89.
PMID: 24764302
Recent progress characterizing the reaction mechanism(s) of fluorescent probes with reactive oxygen species has made it possible to rigorously analyze these reactive species in biological systems. We have developed rapid...
8.
Walsh K, Minamide L, Kane S, Shaw A, Brown D, Pulford B, et al.
PLoS One
. 2014 Apr;
9(4):e95995.
PMID: 24760020
Neurites of neurons under acute or chronic stress form bundles of filaments (rods) containing 1∶1 cofilin∶actin, which impair transport and synaptic function. Rods contain disulfide cross-linked cofilin and are induced...
9.
Diebold B, Smith S, Li Y, Lambeth J
Antioxid Redox Signal
. 2014 Feb;
23(5):375-405.
PMID: 24512192
Significance: NOX2 is important for host defense, and yet is implicated in a large number of diseases in which inflammation plays a role in pathogenesis. These include acute and chronic...
10.
Jones R, Luo L, Ardita C, Richardson A, Kwon Y, Mercante J, et al.
EMBO J
. 2013 Oct;
32(23):3017-28.
PMID: 24141879
The resident prokaryotic microbiota of the metazoan gut elicits profound effects on the growth and development of the intestine. However, the molecular mechanisms of symbiotic prokaryotic-eukaryotic cross-talk in the gut...