J Chuck Harrell
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Explore the profile of J Chuck Harrell including associated specialties, affiliations and a list of published articles.
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67
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2335
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Recent Articles
1.
Wall B, Ogata J, Nguyen M, McClay J, Harrell J, Dozmorov M
bioRxiv
. 2025 Feb;
PMID: 39975128
Short-read sequencing data can be affected by alignment artifacts in certain genomic regions. Removing reads overlapping these exclusion regions, previously known as Blacklists, help to potentially improve biological signal. Tools...
2.
Dozmorov M, Marshall M, Rashid N, Grible J, Valentine A, Olex A, et al.
Sci Rep
. 2024 Dec;
14(1):30519.
PMID: 39690151
No abstract available.
3.
Altman J, Olex A, Zboril E, Walker C, Boyd D, Myrick R, et al.
Clin Transl Med
. 2024 Oct;
14(10):e70044.
PMID: 39417215
Background: Breast cancer's complex transcriptional landscape requires an improved understanding of cellular diversity to identify effective treatments. The study of genetic variations among breast cancer subtypes at single-cell resolution has...
4.
Wall B, Nguyen M, Harrell J, Dozmorov M
Methods Mol Biol
. 2024 Sep;
2856:357-400.
PMID: 39283464
Three-dimensional (3D) chromatin interactions, such as enhancer-promoter interactions (EPIs), loops, topologically associating domains (TADs), and A/B compartments, play critical roles in a wide range of cellular processes by regulating gene...
5.
A triple hormone receptor ER, AR, and VDR signature is a robust prognosis predictor in breast cancer
Omar M, Harrell J, Tamimi R, Marchionni L, Erdogan C, Nakshatri H, et al.
Breast Cancer Res
. 2024 Sep;
26(1):132.
PMID: 39272208
Background: Despite evidence indicating the dominance of cell-of-origin signatures in molecular tumor patterns, translating these genome-wide patterns into actionable insights has been challenging. This study introduces breast cancer cell-of-origin signatures...
6.
Bittman-Soto X, Thomas E, Ganshert M, Mendez-Santacruz L, Harrell J
Cancers (Basel)
. 2024 May;
16(10).
PMID: 38791938
Advancements in cell culturing techniques have allowed the development of three-dimensional (3D) cell culture models sourced directly from patients' tissues and tumors, faithfully replicating the native tissue environment. These models...
7.
Shen S, Radhakrishnan S, Harrell J, Puchalapalli M, Koblinski J, Clevenger C
Endocrinology
. 2024 May;
165(6).
PMID: 38713636
Prolactin and its receptor (PRLr) in humans are significantly involved in breast cancer pathogenesis. The intermediate form of human PRLr (hPRLrI) is produced by alternative splicing and has a novel...
8.
Wall B, Nguyen M, Harrell J, Dozmorov M
ArXiv
. 2024 Mar;
PMID: 38495565
Three-Dimensional (3D) chromatin interactions, such as enhancer-promoter interactions (EPIs), loops, Topologically Associating Domains (TADs), and A/B compartments play critical roles in a wide range of cellular processes by regulating gene...
9.
Byers H, Brooks A, Vangala J, Grible J, Feygin A, Clevenger C, et al.
Sci Rep
. 2023 Sep;
13(1):15843.
PMID: 37739987
Proteasomes are multi-subunit complexes that specialize in protein degradation. Cancer cells exhibit a heightened dependence on proteasome activity, presumably to support their enhanced proliferation and other cancer-related characteristics. Here, a...
10.
Zboril E, Grible J, Boyd D, Hairr N, Leftwich T, Esquivel M, et al.
Cancers (Basel)
. 2023 Jun;
15(12).
PMID: 37370789
Breast cancer alone accounts for the majority of cancer deaths among women, with the most commonly diagnosed subtype being estrogen receptor positive (ER+). Survival has greatly improved for patients with...