J Chuck Harrell
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Explore the profile of J Chuck Harrell including associated specialties, affiliations and a list of published articles.
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67
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2335
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Recent Articles
11.
Dozmorov M, Marshall M, Rashid N, Grible J, Valentine A, Olex A, et al.
Sci Rep
. 2023 May;
13(1):7522.
PMID: 37160896
No abstract available.
12.
Ogata J, Mu W, Davis E, Xue B, Harrell J, Sheffield N, et al.
Bioinformatics
. 2023 Apr;
39(4).
PMID: 37067481
Summary: Exclusion regions are sections of reference genomes with abnormal pileups of short sequencing reads. Removing reads overlapping them improves biological signal, and these benefits are most pronounced in differential...
13.
Dozmorov M, Marshall M, Rashid N, Grible J, Valentine A, Olex A, et al.
Sci Rep
. 2023 Apr;
13(1):5420.
PMID: 37012431
Changes in the three-dimensional (3D) structure of the genome are an emerging hallmark of cancer. Cancer-associated copy number variants and single nucleotide polymorphisms promote rewiring of chromatin loops, disruption of...
14.
Boyd D, Zboril E, Olex A, Leftwich T, Hairr N, Byers H, et al.
Cancers (Basel)
. 2023 Mar;
15(5).
PMID: 36900375
Basal-like triple-negative breast cancer (TNBC) tumor cells are difficult to eliminate due to resistance mechanisms that promote survival. While this breast cancer subtype has low PIK3CA mutation rates when compared...
15.
Jacob S, Turner T, Cai J, Floros K, Yu A, Coon C, et al.
PNAS Nexus
. 2023 Jan;
1(5):pgac232.
PMID: 36712364
Triple negative breast cancer (TNBC) accounts for over 30% of all breast cancer (BC)-related deaths, despite accounting for only 10% to 15% of total BC cases. Targeted therapy development has...
16.
Rashid N, Boyd D, Olex A, Grible J, Duong A, Alzubi M, et al.
Sci Rep
. 2022 Dec;
12(1):21248.
PMID: 36482068
The goals of this study were to identify transcriptomic changes that arise in basal-like breast cancer cells during the development of resistance to epidermal growth factor receptor inhibitors (EGFRi) and...
17.
Wijesinghe K, Kanak M, Harrell J, Dhakal S
ACS Sens
. 2022 Mar;
7(4):1086-1094.
PMID: 35312280
MicroRNAs (miRNAs) play a crucial role in regulating gene expression and have been linked to many diseases. Therefore, sensitive and accurate detection of disease-linked miRNAs is vital to the emerging...
18.
Hampton J, Peterson E, Katner S, Turner T, Alzubi M, Harrell J, et al.
Mol Cancer Ther
. 2021 Nov;
21(2):271-281.
PMID: 34815360
Triple-negative breast cancer (TNBC) is a subtype of breast cancer lacking targetable biomarkers. TNBC is known to be most aggressive and when metastatic is often drug-resistant and uncurable. Biomarkers predicting...
19.
Rashid N, Hairr N, Murray G, Olex A, Leftwich T, Grible J, et al.
Transl Oncol
. 2021 Oct;
14(12):101235.
PMID: 34628286
An estimated 284,000 Americans will be diagnosed with breast cancer in 2021. Of these individuals, 15-20% have basal-like triple-negative breast cancer (TNBC), which is known to be highly metastatic. Chemotherapy...
20.
Woock A, Grible J, Olex A, Harrell J, Zot P, Idowu M, et al.
Sci Rep
. 2021 Jun;
11(1):13506.
PMID: 34188118
In breast cancer, prolactin-induced activation of the transcription factor STAT5a results from the phosphorylation of STAT5a tyrosine residue 694. However, its role in mammary oncogenesis remains an unsettled debate as...