J C Metcalfe
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Explore the profile of J C Metcalfe including associated specialties, affiliations and a list of published articles.
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163
Citations
2973
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Recent Articles
21.
Byrne C, Wareham N, Martensz N, Humphries S, Metcalfe J, Grainger D
Atherosclerosis
. 1998 Sep;
140(1):45-53.
PMID: 9733214
Whether the post-prandial lipemic response is linked to potentially pro-atherogenic and/or prothrombotic changes in plasminogen activator inhibitor (PAI) and transforming growth factor-beta (TGF-beta) is uncertain. The aim of our study...
22.
Transforming growth factor-beta dynamically regulates vascular smooth muscle differentiation in vivo
Grainger D, Metcalfe J, Grace A, Mosedale D
J Cell Sci
. 1998 Sep;
111 ( Pt 19):2977-88.
PMID: 9730989
Variations in the levels of smooth muscle-specific isoforms of contractile proteins have been reported to occur in many different vascular diseases. However, although much work has been done in vitro...
23.
Oklu R, Metcalfe J, Hesketh T, Kemp P
FEBS Lett
. 1998 Apr;
425(2):281-5.
PMID: 9559666
Latent transforming growth factor-beta binding protein-1 (LTBP-1), plays an important role in controlling localisation and activation of transforming growth factor-beta (TGF-beta). We show that alternative splicing generates a form of...
24.
Lacy-Hulbert A, Metcalfe J, Hesketh R
FASEB J
. 1998 Apr;
12(6):395-420.
PMID: 9535213
Electrification in developed countries has progressively increased the mean level of extremely low-frequency electromagnetic fields (ELF-EMFs) to which populations are exposed; these humanmade fields are substantially above the naturally occurring...
25.
Grainger D, Byrne C, Witchell C, Metcalfe J
J Lipid Res
. 1997 Dec;
38(11):2344-52.
PMID: 9392432
Elevated plasma concentrations of low density lipoprotein (LDL) and very-low density lipoprotein (VLDL) have been correlated with the development of atherosclerosis. These lipoproteins may promote atherogenesis by direct deposition of...
26.
Reckless J, Metcalfe J, Grainger D
Circulation
. 1997 Mar;
95(6):1542-8.
PMID: 9118523
Background: Apolipoprotein E (apo E) knockout mice develop severe vascular lipid lesions resembling human atherosclerotic plaques, irrespective of the fat content of their diet. Methods And Results: Oral tamoxifen (TMX)...
27.
Lawn R, Pearle A, Kunz L, Rubin E, Reckless J, Metcalfe J, et al.
J Biol Chem
. 1996 Dec;
271(49):31367-71.
PMID: 8940144
Apolipoprotein(a) (apo(a)), the distinguishing protein of atherogenic lipoprotein(a), directs accumulation of the lipoprotein(a) particle to sites in the arterial wall where atherosclerotic lipid lesions develop in man and in transgenic...
28.
Vandenberg J, Carter N, Bethell H, Nogradi A, Ridderstrale Y, Metcalfe J, et al.
Am J Physiol
. 1996 Dec;
271(6 Pt 1):C1838-46.
PMID: 8997183
Membrane-bound carbonic anhydrase (CA) has recently been identified in mammalian cardiac tissue. In this study, we have investigated the histochemical location and functional role of CA in the ferret heart....
29.
Mosedale D, Metcalfe J, Grainger D
J Histochem Cytochem
. 1996 Sep;
44(9):1043-50.
PMID: 8773570
There is a growing trend towards the objective quantification of immunohistochemical staining. However, quantification has not been used previously to optimize the original published immunohistochemical methods. We present a quantitative...
30.
Grace A, Metcalfe J, Weissberg P, Bethell H, Vandenberg J
Am J Physiol
. 1996 Jun;
270(6 Pt 1):C1687-94.
PMID: 8764151
The Na+/H+ antiport and Na(+)-HCO3- coinflux carrier contribute to recovery from intracellular acidosis in cardiac tissue. The effects of angiotensin II (10(-12)-10(-6) M) on H+ fluxes after intracellular acid loading...