J C Metcalfe
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Explore the profile of J C Metcalfe including associated specialties, affiliations and a list of published articles.
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163
Citations
2973
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Recent Articles
11.
Grainger D, Mosedale D, Metcalfe J, Bottinger E
J Cell Sci
. 2000 Jun;
113 ( Pt 13):2355-61.
PMID: 10852815
Transforming growth factor-(beta) (TGF(beta)) has a wide range of activities on vascular cells and inflammatory cells, suggesting it may have different functions during various stages of atherogenesis. We report that...
12.
Smith G, Dixon H, Kirschenlohr H, Grace A, Metcalfe J, Vandenberg J
Biochem J
. 2000 Mar;
346 Pt 2:393-402.
PMID: 10677358
The measurement of cardiac Ca(2+) transients using spectroscopic Ca(2+) indicators is significantly affected by the buffering properties of the indicators. The aim of the present study was to construct a...
13.
Kirschenlohr H, Grace A, Vandenberg J, Metcalfe J, Smith G
Biochem J
. 2000 Mar;
346 Pt 2:385-91.
PMID: 10677357
Spectroscopic Ca(2+)-indicators are thought to report values of free intracellular Ca(2+) concentration ([Ca(2+)](i)) that may differ from unperturbed values because they add to the buffering capacity of the tissue. To...
14.
Grainger D, Mosedale D, Metcalfe J
Cytokine Growth Factor Rev
. 2000 Mar;
11(1-2):133-45.
PMID: 10708961
The cytokine transforming growth factor-beta (TGF-beta) was initially purified from human platelets, a rich source of this protein. In addition to platelets, TGF-beta1 is also found in other blood fractions,...
15.
Martin K, Cooper W, Metcalfe J, Kemp P
Biochem J
. 2000 Jan;
345 Pt 3:529-33.
PMID: 10642511
Members of the three-zinc-finger family of transcription factors play an important role in determining basal transcription. We have cloned mouse BTEB3 (mBTEB3), a new member of the basic transcription element...
16.
Kemp P, Metcalfe J
Biochem J
. 2000 Jan;
345 Pt 3:445-51.
PMID: 10642500
Serum response factor (SRF) is a key transcriptional activator of the c-fos gene and of muscle-specific gene expression. We have identified four forms of the SRF coding sequence, SRF-L (the...
17.
Reckless J, Rubin E, Verstuyft J, Metcalfe J, Grainger D
Circulation
. 1999 May;
99(17):2310-6.
PMID: 10226098
Background: Apolipoprotein (apo)(a) transgenic mice and C57BL/6 mice fed a high fat diet develop similar-sized lipid lesions, but lesions in apo(a) mice are devoid of macrophages. We used this observation...
18.
Grainger D, Heathcote K, Chiano M, Snieder H, Kemp P, Metcalfe J, et al.
Hum Mol Genet
. 1999 Jan;
8(1):93-7.
PMID: 9887336
The concentration of transforming growth factor beta (TGF-beta) in plasma has been correlated with the development of several diseases, including atherosclerosis and certain forms of cancer. However, the mechanisms that...
19.
Syrris P, Carter N, Metcalfe J, Kemp P, Grainger D, Kaski J, et al.
Clin Sci (Lond)
. 1998 Dec;
95(6):659-67.
PMID: 9831690
1. Transforming growth factor-beta1 is a cytokine with a very wide spectrum of biological activities. Previous studies have shown that it is involved in a number of physiological and pathological...
20.
Oklu R, Hesketh T, Metcalfe J, Kemp P
FEBS Lett
. 1998 Oct;
435(2-3):143-8.
PMID: 9762896
Latent transforming growth factor beta binding protein-1 (LTBP1) is important in regulating the localisation and activation of transforming growth factor beta(TGFbeta). Three forms of LTBP1 mRNA have previously been described,...