J C Kleinjans
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Explore the profile of J C Kleinjans including associated specialties, affiliations and a list of published articles.
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96
Citations
533
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Recent Articles
1.
Jiang J, Messner S, Kelm J, van Herwijnen M, Jennen D, Kleinjans J, et al.
Toxicol Lett
. 2019 May;
312:34-44.
PMID: 31059760
Inflammation is one of the factors that may increase the sensitivity of hepatic cells to acetaminophen (APAP) induced toxicity. To investigate the mechanisms, we exposed 3-dimensional (3D) Human Liver Microtissues,...
2.
Hardt C, Beber M, Rasche A, Kamburov A, Hebels D, Kleinjans J, et al.
Database (Oxford)
. 2016 Apr;
2016.
PMID: 27074805
Motivation: Extensive drug treatment gene expression data have been generated in order to identify biomarkers that are predictive for toxicity or to classify compounds. However, such patterns are often highly...
3.
Hochstenbach K, van Leeuwen D, Gmuender H, Gottschalk R, Stolevik S, Nygaard U, et al.
Toxicol Sci
. 2012 Jun;
129(2):315-24.
PMID: 22738990
A crucial period for the development of the immune system occurs in utero. This results in a high fetal vulnerability to immunotoxic exposure, and indeed, immunotoxic effects have been reported,...
4.
Vermeer I, Engels L, Pachen D, Dallinga J, Kleinjans J, Van Maanen J
Gastroenterology
. 2001 Aug;
121(3):517-25.
PMID: 11522734
Background & Aims: This study evaluated the effect of long-term gastric acid suppressive therapy with omeprazole on intragastric levels of carcinogenic N-nitrosamines and related parameters. Methods: Forty-five patients on long-term...
5.
Godschalk R, Dallinga J, Wikman H, Risch A, Kleinjans J, Bartsch H, et al.
Pharmacogenetics
. 2001 Jul;
11(5):389-98.
PMID: 11470992
The formation of DNA and protein adducts by environmental pollutants is modulated by host polymorphisms in genes that encode metabolizing enzymes. In our study on 67 smokers, aromatic-DNA adduct levels...
6.
Besaratinia A, Besarati Nia A, Schooten F, Schilderman P, de Kok T, Haenen G, et al.
Carcinogenesis
. 2001 Mar;
22(3):395-401.
PMID: 11238178
We investigated the effects of smoking-induced oxidative stress in healthy volunteers (21 smokers versus 24 non-smokers) by quantifying various markers of oxidative DNA damage and repair, and antioxidative defense mechanisms....
7.
de Kok T, Moonen E, van der Ent F, Engels L, Kleinjans J
Cancer Causes Control
. 2001 Jan;
11(10):975-6.
PMID: 11142532
No abstract available.
8.
Besaratinia A, Besarati Nia A, van Straaten H, Godschalk R, van Zandwijk N, Balm A, et al.
Environ Mol Mutagen
. 2000 Oct;
36(2):127-33.
PMID: 11013411
Tobacco smoking is a major risk factor for oral cancer; mouth floor and buccal mucosa are among the most and least cancer-prone subsites, respectively, in the oral cavity. We investigated...
9.
Schilderman P, Maas L, Pachen D, de Kok T, Kleinjans J, Schooten F
Environ Mol Mutagen
. 2000 Oct;
36(2):79-86.
PMID: 11013405
It is known that lower-chlorinated biphenyls are metabolically activated to electrophilic quinoid species capable of binding to DNA. Also, certain metabolites are capable of redox cycling, thereby increasing oxidative stress...
10.
Besaratinia A, Besarati Nia A, van Straaten H, Kleinjans J, Schooten F
Mutat Res
. 2000 Jul;
468(2):125-35.
PMID: 10882891
Tobacco smoke constituents, 4-aminobiphenyl (4-ABP) and polycyclic aromatic hydrocarbons (PAH) possess carcinogenic properties as their reactive metabolites form DNA adducts. We studied the formation of 4-ABP- and PAH-DNA adducts in...