T M de Kok
Overview
Explore the profile of T M de Kok including associated specialties, affiliations and a list of published articles.
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20
Citations
147
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Recent Articles
1.
Jiang J, Messner S, Kelm J, van Herwijnen M, Jennen D, Kleinjans J, et al.
Toxicol Lett
. 2019 May;
312:34-44.
PMID: 31059760
Inflammation is one of the factors that may increase the sensitivity of hepatic cells to acetaminophen (APAP) induced toxicity. To investigate the mechanisms, we exposed 3-dimensional (3D) Human Liver Microtissues,...
2.
Jiang J, Mathijs K, Timmermans L, Claessen S, Hecka A, Weusten J, et al.
Data Brief
. 2017 Aug;
14:462-468.
PMID: 28831409
The inflammatory stress has been associated with an increase in susceptibility to idiosyncratic drug-induced liver injury (DILI). However, the molecular mechanisms of this inflammation-associated idiosyncratic drug hepatotoxicity remain unknown. We...
3.
Jiang J, Mathijs K, Timmermans L, Claessen S, Hecka A, Weusten J, et al.
Toxicol Appl Pharmacol
. 2017 Jul;
332:100-108.
PMID: 28733206
The mechanisms of idiosyncratic drug-induced hepatotoxicity remain largely unclear. It has demonstrated that the drug idiosyncrasy is potentiated in the context of inflammation and intracellular ceramides may play a role...
4.
Burley V, Greenwood D, Hepworth S, Fraser L, de Kok T, van Breda S, et al.
Br J Cancer
. 2010 Oct;
103(11):1749-54.
PMID: 20959829
Background: No studies to date have demonstrated a clear association with breast cancer risk and dietary exposure to acrylamide. Methods: A 217-item food frequency questionnaire was used to estimate dietary...
5.
Weijenberg M, Aardening P, de Kok T, De Goeij A, van den Brandt P
Mutat Res
. 2008 Feb;
652(1):54-64.
PMID: 18296105
Since a KRAS oncogene mutation is an early event in colorectal cancer development and cigarette smoking is thought to have an effect on early stages of colorectal tumorigenesis, smoking, especially...
6.
Besaratinia A, Besarati Nia A, Schooten F, Schilderman P, de Kok T, Haenen G, et al.
Carcinogenesis
. 2001 Mar;
22(3):395-401.
PMID: 11238178
We investigated the effects of smoking-induced oxidative stress in healthy volunteers (21 smokers versus 24 non-smokers) by quantifying various markers of oxidative DNA damage and repair, and antioxidative defense mechanisms....
7.
de Kok T, Moonen E, van der Ent F, Engels L, Kleinjans J
Cancer Causes Control
. 2001 Jan;
11(10):975-6.
PMID: 11142532
No abstract available.
8.
Schilderman P, Maas L, Pachen D, de Kok T, Kleinjans J, Schooten F
Environ Mol Mutagen
. 2000 Oct;
36(2):79-86.
PMID: 11013405
It is known that lower-chlorinated biphenyls are metabolically activated to electrophilic quinoid species capable of binding to DNA. Also, certain metabolites are capable of redox cycling, thereby increasing oxidative stress...
9.
de Kok T, Van Maanen J
Mutat Res
. 2000 Jun;
463(1):53-101.
PMID: 10838209
Colorectal cancer is one of the most common internal malignancies in Western society. The cause of this disease appears to be multifactorial and involves genetic as well as environmental aspects....
10.
Van Maanen J, Albering H, de Kok T, van Breda S, Curfs D, Vermeer I, et al.
Environ Health Perspect
. 2000 May;
108(5):457-61.
PMID: 10811574
In recent years, several studies have addressed a possible relationship between nitrate exposure and childhood type 1 insulin-dependent diabetes mellitus. The present ecologic study describes a possible relation between the...