J C Jaen
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Explore the profile of J C Jaen including associated specialties, affiliations and a list of published articles.
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Articles
29
Citations
247
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Recent Articles
1.
Walters M, Ebsworth K, Berahovich R, Penfold M, Liu S, Al Omran R, et al.
Br J Cancer
. 2014 Jan;
110(5):1179-88.
PMID: 24423923
Background: In experimental models of glioblastoma multiforme (GBM), irradiation (IR) induces local expression of the chemokine CXCL12/SDF-1, which promotes tumour recurrence. The role of CXCR7, the high-affinity receptor for CXCL12,...
2.
Dairaghi D, Zhang P, Wang Y, Seitz L, Johnson D, Miao S, et al.
Clin Pharmacol Ther
. 2011 Apr;
89(5):726-34.
PMID: 21451509
The safety and pharmacokinetic (PK)/pharmacodynamic (PD) profile of the novel CCR1 antagonist CCX354 was evaluated in double-blind, placebo-controlled, single- and multiple-dose phase I studies (1-300 mg/day oral doses). CCX354 was...
3.
Rubenstein S, Baichwal V, Beckmann H, Clark D, Frankmoelle W, Roche D, et al.
J Med Chem
. 2001 Oct;
44(22):3599-605.
PMID: 11606124
The novel anticancer compound T138067 is an irreversible inhibitor of tubulin polymerization. Amides 3-6 were synthesized using standard methodologies and determined to be significantly less lipophilic than T138067 based on...
4.
Tecle H, Schwarz R, Barrett S, Callahan M, Caprathe B, Davis R, et al.
Pharm Acta Helv
. 2000 May;
74(2-3):141-8.
PMID: 10812951
The five muscarinic receptor subtypes (M1-M5) are characterized by seven helices that define a transmembrane cavity which serves as the binding pocket for agonists and antagonists. The five cavities appear...
5.
Cheng D, Espenshade P, Slaughter C, Jaen J, Brown M, Goldstein J
J Biol Chem
. 1999 Jul;
274(32):22805-12.
PMID: 10428865
We describe a permanent line of Chinese hamster ovary cells transfected with a cDNA encoding a truncated form of Site-1 protease (S1P) that is secreted into the culture medium in...
6.
Medina J, Roche D, Shan B, Learned R, Frankmoelle W, Clark D, et al.
Bioorg Med Chem Lett
. 1999 Jul;
9(13):1843-6.
PMID: 10406652
In this report, we describe the synthesis of halogenated benzenesulfonamide compounds and their ability to inhibit the growth of HeLa, MCF-7 and MCF-7/ADR tumor cells in vitro. The multidrug resistance...
7.
Shan B, Medina J, SANTHA E, Frankmoelle W, Chou T, Learned R, et al.
Proc Natl Acad Sci U S A
. 1999 May;
96(10):5686-91.
PMID: 10318945
Microtubules are linear polymers of alpha- and beta-tubulin heterodimers and are the major constituents of mitotic spindles, which are essential for the separation of chromosomes during mitosis. Here we describe...
8.
Plummer J, Cai C, Hays S, Gilmore J, Emmerling M, Michael W, et al.
Bioorg Med Chem Lett
. 1999 Apr;
9(6):815-20.
PMID: 10206542
A series of 2-sulfonyl-4H-3,1-benzoxazinones was prepared that inhibit C1r protease in vitro. Several compounds were found to be selective for C1r verses the related serine protease trypsin. Selected compounds demonstrated...
9.
Augelli-Szafran C, Blankley C, Jaen J, Moreland D, Nelson C, Schwarz R, et al.
J Med Chem
. 1999 Feb;
42(3):356-63.
PMID: 9986705
A series of esters of 1,4-disubstituted tetrahydropyridine carboxylic acids (I) has been synthesized and characterized as potential m1 selective muscarinic receptor antagonists. The affinity of these compounds for the five...
10.
Medina J, Shan B, Beckmann H, FARRELL R, Clark D, Learned R, et al.
Bioorg Med Chem Lett
. 1999 Jan;
8(19):2653-6.
PMID: 9873597
A novel series of pentafluorobenzenesulfonamides has been shown to inhibit the growth of a variety of human tumor cell lines. Among the cell types against which these agents were evaluated...