L D Wise
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Explore the profile of L D Wise including associated specialties, affiliations and a list of published articles.
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63
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458
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Recent Articles
1.
van Vliet L, Rodenhuis N, Wikstrom H, Pugsley T, Serpa K, Meltzer L, et al.
J Med Chem
. 2000 Sep;
43(19):3549-57.
PMID: 11000009
The 2-aminothiazole moiety has proven its value in medicinal chemistry as a stable and lipophilic bioisosteric replacement of a phenol group. This approach has provided dopamine (DA) agonists with good...
2.
Wright J, Gregory T, Kesten S, Boxer P, Serpa K, Meltzer L, et al.
J Med Chem
. 2000 Sep;
43(18):3408-19.
PMID: 10978188
4-[4-(4-Benzylpiperidin-1-yl)but-1-ynyl]phenol (8) and 4-[3-(4-benzylpiperidin-1-yl)prop-1-ynyl]phenol (9) are potent NR1A/2B receptor antagonists (IC(50) values 0.17 and 0.10 microM, respectively). Administered intraperitoneally, they both potentiated the activity of L-DOPA in the unilaterally 6-hydroxydopamine-lesioned...
3.
van Vliet L, Rodenhuis N, Dijkstra D, Wikstrom H, Pugsley T, Serpa K, et al.
J Med Chem
. 2000 Aug;
43(15):2871-82.
PMID: 10956195
Benzopyranoxazine (+)-7 (PD 128907) is the most dopamine (DA) D3 receptor-selective agonist presently known. The only structural feature which distinguishes 7 from the analogous nonselective naphthoxazines is an oxygen atom...
4.
Schelkun R, Yuen P, Serpa K, Meltzer L, Wise L, Whittemore E, et al.
J Med Chem
. 2000 May;
43(9):1892-7.
PMID: 10794706
Previous work in our laboratories investigating compounds with structural similarity to ifenprodil (5) and 6 (CP101,606) resulted in compound 7 as a potent and selective antagonist of the NR1/2B subtype...
5.
Corbin A, Meltzer L, NINTEMAN F, WILEY J, Christoffersen C, Wustrow D, et al.
Neuropharmacology
. 2000 Apr;
39(7):1211-21.
PMID: 10760363
PD 158771 has been described in receptor binding and biochemical tests as a partial agonist at dopamine (DA) D2 and D3 receptors as well as an agonist at serotonin (5-HT)(1A)...
6.
Akunne H, Zoski K, Davis M, Cooke L, Meltzer L, Whetzel S, et al.
Neuropharmacology
. 2000 Apr;
39(7):1197-210.
PMID: 10760362
The neurochemical effects of a novel dopamine (DA) D(2)-like and serotonin (5-HT) 5-HT(1A) agonist, PD 158771, are described. PD 158771 exhibited affinities for human D(2L), D(3) and D(4.2) receptors expressed...
7.
Gregory T, Wright J, Wise L, Meltzer L, Serpa K, Konkoy C, et al.
Bioorg Med Chem Lett
. 2000 Mar;
10(6):527-9.
PMID: 10741546
A series of 1-(heteroarylthioalkyl)-4-benzylpiperidines was rapidly synthesized through the use of parallel synthesis to investigate the binding affinity for the NR1A/2B receptor subtype.
8.
Belliotti T, Wustrow D, Brink W, Zoski K, Shih Y, Whetzel S, et al.
J Med Chem
. 1999 Dec;
42(25):5181-7.
PMID: 10602703
As part of a program to develop dopamine D4 antagonists for the treatment of schizophrenia, we discovered a series of 6- and 7-(phenylpiperazinyl)- and -(phenylpiperidinyl)methylbenzoxazinones through mass screening of our...
9.
Wright J, Gregory T, Boxer P, Meltzer L, Serpa K, Wise L
Bioorg Med Chem Lett
. 1999 Oct;
9(19):2815-8.
PMID: 10522697
4-Benzyl-1-[4-(1H-imidazol-4-yl)but-3-ynyl]piperidine (8) has been identified as a potent antagonist of the NR1A/2B subtype of the NMDA receptor. When dosed orally, this compound potentiates the effects of L-DOPA in the 6-hydroxydopamine-lesioned...
10.
Kesten S, Heffner T, Johnson S, Pugsley T, Wright J, Wise L
J Med Chem
. 1999 Sep;
42(18):3718-25.
PMID: 10479303
The discovery of a series of chromen-2-ones with selective affinity for the dopamine (DA) D4 receptor is described. Target compounds were tested for binding to cloned human DA D2L, D3,...