J Alejandro Lopez
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Explore the profile of J Alejandro Lopez including associated specialties, affiliations and a list of published articles.
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31
Citations
883
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Recent Articles
1.
Mukhiya R, Fleischmann W, Loughland J, Chan J, De Labastida Rivera F, Andrew D, et al.
EBioMedicine
. 2024 Nov;
109:105419.
PMID: 39490199
Background: Human immune responses to infection and vaccination are heterogenous, driven by multiple factors including genetics, environmental exposures and personal infection histories. For malaria caused by Plasmodium falciparum parasites, host...
2.
Dooley N, Chabikwa T, Pava Z, Loughland J, Hamelink J, Berry K, et al.
Nat Commun
. 2023 Nov;
14(1):7387.
PMID: 37968278
Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell subsets, which protects from immunopathogenesis, but also hampers the development of effective anti-parasitic immunity. Understanding malaria induced tolerogenic responses in specific...
3.
Wang Y, De Labastida Rivera F, Edwards C, Frame T, Engel J, Bukali L, et al.
J Clin Invest
. 2023 Oct;
133(19).
PMID: 37781920
The development of highly effective malaria vaccines and improvement of drug-treatment protocols to boost antiparasitic immunity are critical for malaria elimination. However, the rapid establishment of parasite-specific immune regulatory networks...
4.
Taylor I, Lopez J
J Cancer Res Clin Oncol
. 2023 Apr;
149(10):8117-8129.
PMID: 37031291
Purpose: Pancreatic ductal adenocarcinoma (PDAC) remains a common and difficult cancer to treat. Surgical resection and chemotherapy are standard of care and clinical outcomes remain poor. Oncolytic adenoviruses are a...
5.
Lu X, He Y, Johnston R, Nanayakarra D, Sankarasubramanian S, Lopez J, et al.
J Exp Clin Cancer Res
. 2022 Dec;
41(1):355.
PMID: 36539830
Background: High-grade serous ovarian carcinomas (HGSCs) are a heterogeneous subtype of epithelial ovarian cancers and include serous cancers arising in the fallopian tube and peritoneum. These cancers are now subdivided...
6.
Rashidieh B, Shohayeb B, Bain A, Fortuna P, Sinha D, Burgess A, et al.
PLoS Genet
. 2021 Oct;
17(10):e1009334.
PMID: 34710087
Homozygous nonsense mutations in CEP55 are associated with several congenital malformations that lead to perinatal lethality suggesting that it plays a critical role in regulation of embryonic development. CEP55 has...
7.
Ryan R, Seymour J, Loukas A, Lopez J, Ikonomopoulou M, Miles J
Front Immunol
. 2021 May;
12:661082.
PMID: 34040609
Venoms are complex mixtures of toxic compounds delivered by bite or sting. In humans, the consequences of envenomation range from self-limiting to lethal. Critical host defence against envenomation comprises innate...
8.
Ryan R, Lutzky V, Herzig V, Smallwood T, Potriquet J, Wong Y, et al.
Toxins (Basel)
. 2020 Oct;
12(11).
PMID: 33114591
Venoms act with remarkable specificity upon a broad diversity of physiological targets. Venoms are composed of proteins, peptides, and small molecules, providing the foundation for the development of novel therapeutics....
9.
Assadollahi V, Rashidieh B, Alasvand M, Abdolahi A, Lopez J
J Cell Biochem
. 2019 Mar;
120(8):13046-13055.
PMID: 30916819
Background: Targeted therapy is a novel, promising approach to anticancer treatment that endeavors to overcome drug resistance to traditional chemotherapies. Patients with the L858R mutation in epidermal growth factor receptor...
10.
Kalimutho M, Sinha D, Jeffery J, Nones K, Srihari S, Fernando W, et al.
EMBO Mol Med
. 2018 Aug;
10(9).
PMID: 30108112
The centrosomal protein, CEP55, is a key regulator of cytokinesis, and its overexpression is linked to genomic instability, a hallmark of cancer. However, the mechanism by which it mediates genomic...