Christian R Engwerda
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Explore the profile of Christian R Engwerda including associated specialties, affiliations and a list of published articles.
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122
Citations
4517
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Recent Articles
1.
Kong G, Song Y, Yan Y, Calderazzo S, Saddala M, De Labastida Rivera F, et al.
Neuron
. 2025 Jan;
113(5):684-700.e8.
PMID: 39809279
Spinal cord injury (SCI) increasingly affects aged individuals, where functional impairment and mortality are highest. However, the aging-dependent mechanisms underpinning tissue damage remain elusive. Here, we find that natural killer-like...
2.
Boyle M, Engwerda C, Jagannathan P
Nat Rev Immunol
. 2024 Jun;
24(9):637-653.
PMID: 38862638
Malaria, caused by infection with Plasmodium parasites, drives multiple regulatory responses across the immune landscape. These regulatory responses help to protect against inflammatory disease but may in some situations hamper...
3.
Kausar G, Bhushan Chauhan S, Roy R, Verma V, Pandey S, Niyaz A, et al.
PLoS Negl Trop Dis
. 2024 Apr;
18(4):e0012112.
PMID: 38669292
Visceral leishmaniasis (VL) is a potentially fatal parasitic infection caused by Leishmania donovani in India. L. donovani is an obligate intracellular protozoan residing mostly in macrophages of the reticuloendothelial system...
4.
Gao Y, Souza-Fonseca-Guimaraes F, Bald T, Ng S, Young A, Ngiow S, et al.
Nat Immunol
. 2024 Mar;
25(5):925-926.
PMID: 38514890
No abstract available.
5.
Ng S, De Labastida Rivera F, Yan J, Corvino D, Das I, Zhang P, et al.
Nat Immunol
. 2024 Feb;
25(4):716.
PMID: 38360937
No abstract available.
6.
Dooley N, Chabikwa T, Pava Z, Loughland J, Hamelink J, Berry K, et al.
Nat Commun
. 2023 Nov;
14(1):7387.
PMID: 37968278
Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell subsets, which protects from immunopathogenesis, but also hampers the development of effective anti-parasitic immunity. Understanding malaria induced tolerogenic responses in specific...
7.
Edwards C, Engel J, De Labastida Rivera F, Ng S, Corvino D, Montes de Oca M, et al.
JCI Insight
. 2023 Nov;
8(24).
PMID: 37917177
Control of visceral leishmaniasis (VL) depends on proinflammatory Th1 cells that activate infected tissue macrophages to kill resident intracellular parasites. However, proinflammatory cytokines produced by Th1 cells can damage tissues...
8.
Wang Y, De Labastida Rivera F, Edwards C, Frame T, Engel J, Bukali L, et al.
J Clin Invest
. 2023 Oct;
133(19).
PMID: 37781920
The development of highly effective malaria vaccines and improvement of drug-treatment protocols to boost antiparasitic immunity are critical for malaria elimination. However, the rapid establishment of parasite-specific immune regulatory networks...
9.
Edwards C, Ng S, De Labastida Rivera F, Corvino D, Engel J, Montes de Oca M, et al.
J Clin Invest
. 2023 Feb;
133(4).
PMID: 36787259
No abstract available.
10.
Edwards C, Ng S, De Labastida Rivera F, Corvino D, Engel J, Montes de Oca M, et al.
J Clin Invest
. 2023 Jan;
133(1).
PMID: 36594463
Control of intracellular parasites responsible for malaria requires host IFN-γ+T-bet+CD4+ T cells (Th1 cells) with IL-10 produced by Th1 cells to mitigate the pathology induced by this inflammatory response. However,...