Dominik Thimm
Overview
Explore the profile of Dominik Thimm including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
17
Citations
252
Followers
0
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Recent Articles
1.
Ossendorff R, Thimm D, Wirtz D, Schildberg F
Dtsch Arztebl Int
. 2024 Jul;
121(10):343-344.
PMID: 38973409
No abstract available.
2.
Ossendorff R, Thimm D, Wirtz D, Schildberg F
Dtsch Arztebl Int
. 2023 Jul;
120(35-36):575-581.
PMID: 37427991
Background: Osteoarthritis is a degenerative joint disease that is becoming increasingly common as the population ages. Conservative treatment for hip or knee osteoarthritis has been limited to pain control. Intra-articular...
3.
Al Hamwi G, Riedel Y, Clemens S, Namasivayam V, Thimm D, Muller C
Pharmacol Ther
. 2022 Aug;
238:108259.
PMID: 35934214
MAS-related G protein-coupled receptors (GPCRs) of subfamily X, designated MRGPRX, are primate-specific orphan receptors that belong to the δ-branch of rhodopsin-like, class A GPCRs. Four distinct subtypes exist, MRGPRX1, -2,...
4.
Breidenbach J, Lemke C, Pillaiyar T, Schakel L, Al Hamwi G, Diett M, et al.
Angew Chem Int Ed Engl
. 2021 Mar;
60(18):10423-10429.
PMID: 33655614
The main protease of SARS-CoV-2 (M ), the causative agent of COVID-19, constitutes a significant drug target. A new fluorogenic substrate was kinetically compared to an internally quenched fluorescent peptide...
5.
Wolf K, Kuhn H, Boehm F, Gebhardt L, Glaudo M, Agelopoulos K, et al.
J Allergy Clin Immunol
. 2021 Feb;
148(2):506-522.e8.
PMID: 33617860
Background: Mas gene-related G protein-coupled receptors (MRGPRs) are a G protein-coupled receptor family responsive to various exogenous and endogenous agonists, playing a fundamental role in pain and itch sensation. The...
6.
Danish A, Gedschold R, Hinz S, Schiedel A, Thimm D, Bedner P, et al.
Int J Mol Sci
. 2021 Feb;
22(3).
PMID: 33572565
Connexin gap junctions (Cx GJs) enable the passage of small molecules and ions between cells and are therefore important for cell-to-cell communication. Their dysfunction is associated with diseases, and small...
7.
Pillaiyar T, Kose M, Namasivayam V, Sylvester K, Borges G, Thimm D, et al.
ACS Omega
. 2018 Jul;
3(3):3365-3383.
PMID: 30023867
GPR84, a G protein-coupled receptor that is activated by medium-chain (hydroxy)fatty acids, appears to play an important role in inflammation, immunity, and cancer. Recently, 6-octylaminouracil () has been reported to...
8.
Pillaiyar T, Kose M, Sylvester K, Weighardt H, Thimm D, Borges G, et al.
J Med Chem
. 2017 Apr;
60(9):3636-3655.
PMID: 28406627
The G protein-coupled receptor GPR84, which is activated by (hydroxy)fatty acids, is highly expressed on immune cells. Recently, 3,3'-diindolylmethane was identified as a heterocyclic, nonlipid-like GPR84 agonist. We synthesized a...
9.
Muller C, Thimm D, Baringhaus K
ChemMedChem
. 2017 Jan;
12(1):100-103.
PMID: 28044422
Pushing the frontiers of medicinal chemistry: Christa Müller, Dominik Thimm, and Karl-Heinz Baringhaus look back at the events of the 2016 Frontiers in Medicinal Chemistry (FiMC) Conference held in Bonn,...
10.
Thimm D, Funke M, Meyer A, Muller C
J Med Chem
. 2013 Jul;
56(17):7084-99.
PMID: 23888932
The potent and selective GPR35 agonist 6-bromo-8-(4-methoxybenzamido)-4-oxo-4H-chromene-2-carboxylic acid (12) was obtained in tritium-labeled form, designated [(3)H]PSB-13253, with a specific activity of 36 Ci (1.33 TBq)/mmol. Radiolabeling was achieved by methylation...