Ivanka Tsakovska
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Explore the profile of Ivanka Tsakovska including associated specialties, affiliations and a list of published articles.
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30
Citations
299
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Recent Articles
1.
Vezenkov L, Tsekova D, Kostadinova I, Mihaylova R, Lozanov V, Vassilev N, et al.
Curr Alzheimer Res
. 2023 Jun;
20(2):120-129.
PMID: 37278042
Background: Alzheimer's disease (AD) and Multiple sclerosis (MS) lead to neurodegenerative processes negatively affecting millions of people worldwide. Their treatment is still difficult and practically incomplete. One of the most...
2.
Alov P, Stoimenov H, Lessigiarska I, Pencheva T, Tzvetkov N, Pajeva I, et al.
Int J Mol Sci
. 2022 Nov;
23(21).
PMID: 36362434
The conventional treatment of neurodegenerative diseases (NDDs) is based on the "one molecule-one target" paradigm. To combat the multifactorial nature of NDDs, the focus is now shifted toward the development...
3.
Alov P, Al Sharif M, Najdenski H, Pencheva T, Tsakovska I, Zaharieva M, et al.
Molecules
. 2022 May;
27(10).
PMID: 35630751
The increased use of polyphenols nowadays poses the need for identification of their new pharmacological targets. Recently, structure similarity-based virtual screening of DrugBank outlined pseudopurpurin, a hydroxyanthraquinone from spp., as...
4.
Alov P, Tsakovska I, Pajeva I
Molecules
. 2022 Apr;
27(7).
PMID: 35408486
Quantitative structure-activity relationships (QSAR) are a widely used methodology allowing not only a better understanding of the mechanisms of chemical reactions, including radical scavenging, but also to predict the relevant...
5.
Alov P, Al Sharif M, Aluani D, Chegaev K, Dinic J, Divac Rankov A, et al.
Front Pharmacol
. 2022 Mar;
13:831791.
PMID: 35321325
Sdox is a hydrogen sulfide (HS)-releasing doxorubicin effective in P-glycoprotein-overexpressing/doxorubicin-resistant tumor models and not cytotoxic, as the parental drug, in H9c2 cardiomyocytes. The aim of this study was the assessment...
6.
Tsakovska I, Diukendjieva A, Worth A
Methods Mol Biol
. 2022 Feb;
2425:259-289.
PMID: 35188637
In this chapter, we give a brief overview of the regulatory requirements for acute systemic toxicity information in the European Union, and we review structure-based computational models that are available...
7.
Podolski-Renic A, Dinic J, Stankovic T, Tsakovska I, Pajeva I, Tuccinardi T, et al.
Cancers (Basel)
. 2021 Nov;
13(21).
PMID: 34771471
Tyrosine kinase inhibitors (TKIs) often interact with the multidrug resistant (MDR) phenotype of cancer cells. In some cases, TKIs increase the susceptibility of MDR cancer cells to chemotherapy. As the...
8.
Lessigiarska I, Peng Y, Tsakovska I, Alov P, Lagarde N, Jereva D, et al.
Molecules
. 2021 Nov;
26(21).
PMID: 34770768
The aim of this study was to investigate the chemical space and interactions of natural compounds with sulfotransferases (SULTs) using ligand- and structure-based in silico methods. An in-house library of...
9.
Kancheva V, Dettori M, Fabbri D, Alov P, Angelova S, Slavova-Kazakova A, et al.
Antioxidants (Basel)
. 2021 Apr;
10(4).
PMID: 33921802
Oxidative stress is associated with the increased production of reactive oxygen species or with a significant decrease in the effectiveness of antioxidant enzymes and nonenzymatic defense. The penetration of oxygen...
10.
Ilieva Y, Dimitrova L, Zaharieva M, Kaleva M, Alov P, Tsakovska I, et al.
Toxics
. 2021 Apr;
9(5).
PMID: 33919268
The cytotoxicity and microbicidal capacity of seven organic solvents commonly applied for studying plant extracts and bioactive compounds were systematically investigated based on international standards. Four cell lines of normal...