Andrew P Worth
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Explore the profile of Andrew P Worth including associated specialties, affiliations and a list of published articles.
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Citations
683
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Recent Articles
1.
Worth A, Berggren E, Prieto P
Altern Lab Anim
. 2024 Oct;
53(1):21-25.
PMID: 39475772
The use of adverse effect data from animals as the gold standard in regulatory toxicology has a long tradition dating back to the 1960s. It has also been increasingly criticised,...
2.
Worth A, Berggren E
Toxicol Sci
. 2024 Oct;
203(2):160-165.
PMID: 39361427
The European regulatory framework on chemicals is at a crossroads. There are calls for the framework to be more effective, by better protecting people and the environment. There is also...
3.
Berggren E, Worth A
Regul Toxicol Pharmacol
. 2023 Jun;
142:105431.
PMID: 37315707
The body of EU chemicals legislation has evolved since the 1960s, producing the largest knowledge base on chemicals worldwide. Like any evolving system, however, it has become increasingly diverse and...
4.
Westmoreland C, Bender H, Doe J, Jacobs M, Kass G, Madia F, et al.
Regul Toxicol Pharmacol
. 2022 Sep;
135:105261.
PMID: 36103951
New Approach Methodologies (NAMs) are considered to include any in vitro, in silico or chemistry-based method, as well as the strategies to implement them, that may provide information that could...
5.
Cronin M, Bauer F, Bonnell M, Campos B, Ebbrell D, Firman J, et al.
Regul Toxicol Pharmacol
. 2022 Aug;
135:105249.
PMID: 36041585
Structure-activity relationships (SARs) in toxicology have enabled the formation of structural rules which, when coded as structural alerts, are essential tools in in silico toxicology. Whilst other in silico methods...
6.
Spinu N, Cronin M, Madden J, Worth A
Comput Toxicol
. 2022 Feb;
21:100205.
PMID: 35224319
Toxicology in the 21st Century has seen a shift from chemical risk assessment based on traditional animal tests, identifying apical endpoints and doses that are "safe", to the prospect of...
7.
Spinu N, Cronin M, Lao J, Bal-Price A, Campia I, Enoch S, et al.
Comput Toxicol
. 2022 Feb;
21:100206.
PMID: 35211661
In a century where toxicology and chemical risk assessment are embracing alternative methods to animal testing, there is an opportunity to understand the causal factors of neurodevelopmental disorders such as...
8.
Tsakovska I, Diukendjieva A, Worth A
Methods Mol Biol
. 2022 Feb;
2425:259-289.
PMID: 35188637
In this chapter, we give a brief overview of the regulatory requirements for acute systemic toxicity information in the European Union, and we review structure-based computational models that are available...
9.
Patterson E, Whelan M, Worth A
Comput Toxicol
. 2021 Mar;
17:100144.
PMID: 33681540
New approaches in toxicology based on in vitro methods and computational modelling offer considerable potential to improve the efficiency and effectiveness of chemical hazard and risk assessment in a variety...
10.
Spinu N, Cronin M, Enoch S, Madden J, Worth A
Arch Toxicol
. 2020 May;
94(5):1497-1510.
PMID: 32424443
The quantitative adverse outcome pathway (qAOP) concept is gaining interest due to its potential regulatory applications in chemical risk assessment. Even though an increasing number of qAOP models are being...